Food Science and Human Health


The laboratory of Human Health (College of Food Science and Engineering, Ocean University of China) mainly focuses on the research of aquatic marine chemistry, marine food intensive processing technology, marine food nutrition, the structure and function of marine biological efficacy factor, and marine functional food development. Since the "Eleventh Five-Year Plan", we have chaired/participated in the completion of 12 projects from the National Natural Science Foundation of China, National 863 Program, the National Science and Technology Support Program and the International Science and Technology Cooperation programs. At present, there are five projects from the National Natural Science Foundation, one project from the National Science and Technology Support Program, one project from the Marine Nonprofit Industry Special Scientific Research Funds, and four projects from provincial and ministerial level ongoing. We have won five scientific and technological awards above provincial and ministerial level, including one award of National Science and Technology Progress Second Prize. We have more than 200 academic publications, including more than 80 papers SCI/EI indexed and obtained 30 authorized invention patents. We have built close collaborations with Kyoto University, Hokkaido University, Tokai University, University of Massachusetts, Washington State University, University of Ghent,The Chinese University of Hong Kong, Harvard Medical School, Kasetsart University and Washington University School of Medicine.

There are nine staff members in the laboratory including three professors, three associate professors, one professor level senior engineer, one instructorand one laboratory technician. The research group leader, professor Changhu Xue, is the Taishan Scholars distinguished Professor (2006-), and the principal of the ministry of education "Changjiang Scholars and Innovation Team Development plan" innovation team (2012-2014). There are 11 Ph.D. students and 49 master students currently, as well as 40 Ph.D. and more than 100 masters students formally graduated from our laboratory.

Faculty in this lab

Selected Lab publications

1.YanchaoWang, Yaoguang Chang1, Long Yu, Cuiyu Zhang, Xiaoqi Xu, Yong Xue, Zhaojie Li, Changhu Xue. Crystalline structure and thermal property characterization of chitin fromAntarctic krill (Euphausia superba). Carbohydrate Polymers. 92, (2013),90-97IF 3.479

2.Lili Zhang, Yong Xue, Jie Xu, Zhaojie Li, Changhu Xue. Effects of high-temperature treatment (100°C) on Alaska Pollock (Theragra chalcogramma) surimi gels. Journal of Food Engineering. 115,(2013),115-120IF 2.276

3.Shiguo Chen, Guoyun Li, Nian Wu a, Xin Guo a, Ningbo Liao a, Xingqian Ye, Donghong Liu, Changhu Xue b**, Wengang Chai. Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates. Biochimica et Biophysica Acta. 1830,(2013),3054-3066IF 3.848

4.Haihua Cong, Fang Liu, Zhongwei Tang, Changhu Xue. Dielectric properties of sea cucumbers (Stichopus japonicus) and model foods at 915 MHz. Journal of Food Engineering. 109,(2012), 635-639IF 2.276

5.Qiao-Ming Lou, Yu-Ming Wang, Xiao-Fang Liu and Chang-Hu Xue. LIPID PROFILE AND FATTY ACID COMPOSITIONS IN BODY WALL OF APOSTICHOPUS JAPONICUS (SELENKA). Journal of Food Biochemistry. 36,(2012), 317-321IF 0.756

6.Shiguo Chen, Yaqin Hu, Xinqian Ye, Guoyun Li, Guangli Yu, Changhu Xue b*, Wengang Chai. Sequence determination and anticoagulant and antithrombotic activities of a nove sulfated fucan isolated from the sea cucumber Isostichopus badionotus. Biochimica et Biophysica Acta .1820,(2012),989-1000IF 3.848

7.Xiaofang Liu, Changhu Xue*, Yuming Wang, Zhaojie Li, Yong Xue, Jie Xu. The classification of sea cucumber (Apostichopus japonicus) according to region of origin using multi-element analysis and pattern recognition techniques. Food Control. 23,(2012), 522-527IF 2.738

8.Lingzhao Wang,Changhu Xue,*Yuming Wang,Bao Yang. Extraction of Proteins with Low Fluoride Level from Antarctic Krill (Euphausia superba) and Their Composition Analysis. Journal of food engineering. 59,(2011),6108-6112IF 2.276

9.Guoyun Li, Shiguo Chen, Yuming Wang, Yong Xue, Yaoguang Chang, Zhaojie Li, Jingfeng Wang, Changhu Xue. A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: Purification, structure identification and anticoagulant activity. International Journal of Biological Macromolecules. 49, (2011),1160-1166IF 2.596

10.Jie Xu, Jingjing Duan, Changhu Xue* ,Tingyu Feng, Ping Dong,Tatsuya Sugawara, Takashi Hirata. Analysis and Comparison of Glucocerebroside Species from Three Edible Sea Cucumbers Using Liquid Chromatography_Ion Trap_Time-of-Flight Mass Spectrometry. Journal of Agricultural and Food Chemistry. 59, (2011),12246-12253IF 2.906

11.Shiguo Chen, Changhu Xue,Li’ang Yin, Qingjuan Tang, Guangli Yu, Wengang Chai.Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbers.Carbohydrate Polymers. 83, (2011), 688-696IF 3.479

12.Qin ZHAO, Zhi-dong LIU, Yong XUE, Jing-feng WANG, Hui LI, Qing-juan TANG, Yu-ming WANG, Ping DONG, Chang-hu XUE*. Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology).12,(2011),534-544IF 1.108

13.Jie Xu*,Yu-Ming Wang*,Ting-Yu Feng, Bei Zhang,Tatsuya Sugawara,Chang-HU Xue*.Isolation and Anti-Fatty Liver Activity of a Novel Cerebroside from the Sea Cucumber Acaudina molpadiosdes. Biosci.Biotechnol.Biochen. 75, (2011),1466-1471IF 1.269

14.Yu-Ming Wang, Xiao-Qian Hu,Yong Xue, Zhao-Jie Li,Teruyoshi Yanagita, Chang-Hu Xue*.Study on possible mechanism of orotic acid–induced fatty liver in rats. Nutrition. 27,(2011), 571-575IF 2.859

15.Xiao-Qian Hu, Yu-Ming Wang, Jing-Feng Wang, Yong Xue, Zhao-Jie Li1, Koji Nagao, Teruyoshi Yanagita, Chang-Hu Xue*. Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARa and SREBP-1c signaling. Lipids in Health and Disease. 9,(2010), 25IF 2.015

16.Y. Chang, C. Xue, Q. Tang, D. Li, X. Wu and J. Wang, Chang-Hu Xue*. Isolation and characterization of a sea cucumber fucoidanutilizing marine bacterium. Letters in Applied Microbiology. 50,(2010), 301-307IF 1.629

17.Shiguo Chen, Jingfeng Wang, Changhu Xue, Hui Li, Beibei Sun, Yong Xue, Wengang Chai. Sulfation of a squid ink polysaccharide and its inhibitory effect on tumor cell metastasis. Carbohydrate Polymers. 81, (2010), 560-566IF 3.479

18.Yu-Ming Wang, Bei Zhang, Yong Xue, Zhao-Jie Li, Jing-Feng Wang, Chang-Hu Xue*, Teruyoshi Yanagita. The mechanism of dietary cholesterol effects on lipids metabolism in rats. Lipids in Health and Disease. 9,(2010), 4IF 2.015

19.Qingjuan Tang, Dan Li, Jie Xu,Jingfeng Wang, Yuran Zhao, Zhaojie Li, Changhu Xue*. Mechanism of inactivation of murine norovirus-1 by high pressure processing. International Journal of Food Microbiology. 137,(2010), 186-189IF 3.425

20.Rong Cao,Chang-hu Xue*,Qi Liu. Changes in microbial flora of Pacific oysters (Crassostrea gigas) during refrigerated storage and its shelf-life extension by chitosan. International Journal of Food Microbiology. 131, (2009), 272-276IF 3.425

21.Dan Li, Qingjuan Tang, Jingfeng Wang, Yuming Wang, Qin Zhao, Changhu Xue*. Effects of high-pressure processing on murine norovirus-1 in oysters(Crassostrea gigas) in situ.Food Control. 20,(2009),992-996IF 2.738

22.Qi-Long Shi,Ya Zhao, Hai-Hua Chen,Zhao-Jie Li,Chang-Hu Xue*.Glass transition and state diagram for freeze-dried horse mackerel muscle.Thermochimica Acta. 493,(2009),55-60IF 1.989

23.Feng Li, Hong-ying Liu,Chang-hu Xue, Xue-qian Xina, Jie Xua, Yao-guang Chang, Yong Xue, Li-ang Yina. Simultaneous determination of dimethylamine, trimethylamine and trimethylamine-n-oxide in aquatic products extracts by ion chromatography with non-suppressed conductivity detection. Journal of Chromatography A. 1216,(2009),5924-5926IF 4.612

24.Long Yu, Xiaoqi Xu, Changhu Xue, Yaoguang Chang, Lei Ge, Yanchao Wang, Cuiyu Zhang,Guanchen Liu, Chen He. Enzymatic preparation and structural determination of oligosaccharides derived from sea cucumber (Acaudina molpadioides) fucoidan. Food Chemistry. 139, (2013) ,702-709IF 3.334

25.Long Yu, Lei Ge, Changhu Xue, Yaoguang Chang, Cuiyu Zhang, Xiaoqi Xu,Yanchao Wang. Structural study of fucoidan from sea cucumber Acaudina molpdioides: a fucoidan containing novel tetrafucose repeating unit. Food chemistry. 142,(2013),197-200IF 3.334

26.Xiaoqian Hu,* Zhaojie Li,* Yong Xue, Jie Xu, Changhu Xue, Jingfeng Wang, and Yuming Wang. Dietary Saponins of Sea Cucumber Ameliorate Obesity, Hepatic Steatosis,and Glucose Intolerance in High-Fat Diet–Fed Mice. JOURNAL OF MEDICINAL FOOD J Med Food . 15,(2012), 909-916IF 1.642

27.Hu Hou, Bafang Li, Zhaohui Zhang, Changhu Xue, Guangli Yu, Jingfeng Wang, Yuming Bao,Lin Bu, Jiang Sun, Zhe Peng, Shiwei Su. Moisture absorption and retention properties, and activity in alleviating skin photodamage of collagen polypeptide from marine fish skin. Food Chemistry. 135,(2012), 1432-1439IF 3.334

28.Yuqian Han, Qinchuan Ma, Jie Lu, Yong Xue, Changhu Xue. Optimisation for subcritical fluid extraction of 17-methyltestosterone with 1,1,1,2-tetrafluoroethane for HPLC analysis. Food Chemistry. 135,(2012),2988-2993IF 3.334

29.Yanchao Wang, Wei Su, Cuiyu Zhang, Changhu Xue, Yaoguang Chang, Xiaolin Wu,Qingjuan Tang, Jingfeng Wang. Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage. Food Chemistry. 133,(2012),1414-1419IF 3.334

30.Hu Hou, Yan Fan, Bafang Li, Changhu Xue, Guangli Yu, Zhaohui Zhang, Xue Zhao. Purification and identification of immunomodulating peptides from enzymat hydrolysates of Alaska pollock frame. Food Chemistry. 134,(2012),821-828IF 3.334

31.Tao Zuo, Zhaojie Li, Yingchun Lv, Gaofei Duan, Chunxia Wang, Qingjuan Tang*, Changhu Xue. Rapid identification of sea cucumber species with multiplex-PCR. Food Control. 26,(2012),58-62IF 2.738

32.ChaoWang, Changhu Xue,Yong Xue, Zhaojie Li, Yingchun Lv,Hao Zhang. Quality changes in sea urchin(Strongylocentrotus nudus) during storage in artificial seawater saturated with oxygen,nitrogen and air. Journal of the Science of Food and Agriculture.92,(2012),191-196IF 1.759

33.Yuqian Han, Qinchuan Ma, Jie Lu, Yong Xue, Jie Xu, Changhu Xue. Development and validation of a subcritical fluid extraction and high performance liquid chromatography assay for medroxyprogesterone in aquatic products.Journal of Chromatography B. 897,(2012),90-93IF 4.612

34.Qin Zhao,Yong Xue,Zhi-dong Liu, Hui Li, Jing-feng Wang, Zhao-jie Li,Yu-ming Wang,Ping Dong, Chang-hu Xue. Differential Effects of Sulfated Triterpene Glycosides,Holothurin A1,and 24-Dehydroechinoside A, on Antimetastasic Activity via Regulation of the MMP-9 Signal Pathway. Journal of Food Science. 75,(2010),280-288IF 1.775

35.Yanchao Wang, Yaoguang Chang, Long Yu, Cuiyu Zhang, Xiaoqi Xu, Yong Xue, Zhaojie Li, Changhu Xue.Crystalline structure and thermal property characterization of chitin from Antarctic krill (Euphausiasuperba).Carbohydrate Polymers. 92,(2010),90-97 IF 3.479

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