XU, Zhe

PhD, Associate Professor

Tel: +86-532-80932627；

E-mail: xuzhe@ouc.edu.cn

Pharmaceutical Analysis

Education

2000-2004Bachelor of Engineering,Chemical Engineering and Technology, Huazhong University of Science and Technology, Wuhan, China.

2004-2010Ph.D., Analytical Chemistry,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China (Supervisor: Yinlong GUO)

Working Experience

2011-2013 Postdoctoral Research Fellow, Analytical Chemistry, The University of Texas at Austin, Austin, Texas, USA (Jennifer Brodbelt Group)

2014Senior Scientist, Shanghai ICI R&D and Management Limited, Shanghai, China

2014-presentAssociate Professor, Ocean University of China, Qingdao, China

Research Interests

(1) Development of new mass spectrometry methodologies or strategies for drug discovery;

(2) Application of mass spectrometry in biomolecular analysis;

(3)Pharmaceutical Analysis;

(4) Pharmacokinetic analysis in development of novel pharmaceuticals

Selected Publication

1. Jennifer S. Brodbelt, Zhe Xu, “Chapter 9: Ligand binding to nucleic acids” in “Nucleic Acids in the Gas Phase”, Springer, 2014.

2. Zhe Xu, Jared Shaw, Jennifer Brodbelt*, Differentiation and Distributions of DNA/Cisplatin Crosslinks by Liquid Chromatography-Electrospray Ionization-Infrared Multiphoton Dissociation Mass Spectrometry. Journal of the American Society for Mass Spectrometry2014, 25 (1), 71-79.

3. Zhe Xu, Jared Shaw, Jennifer Brodbelt*, Comparison of MS/MS Methods for Characterization of DNA/Cisplatin Adducts. Journal of the American Society for Mass Spectrometry 2013, 24 (2), 265-273.

4. Zhe Xu, Hao-Yang Wang, Shi-Xin Huang, Yuan-Long Wei, Sheng-Jun Yao, Yin-Long Guo* Determination of β-Lactamase Residues in Milk Using Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry Analytical Chemistry 2010, 82(5), 2113-2118.

5. Zhe Xu, Shengjun Yao, Yuanlong Wei, Jing Zhou, Li Zhang, Cuihong Wang, Yinlong Guo* Monitoring Enzyme Reaction and Screening of Inhibitors of Acetylcholinesterase by Quantitative Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry Journal of the American Society for Mass Spectrometry 2008, 19(12), 1849-1855.

6. Zhe Xu, Zuoding Ding, Xu Xu*, Xiaoan Xie Enantioseparation of 2-aryl-1,3-dicarbonyl analogues by High Performance Liquid Chromatography Using Polysaccharide Type Chiral Stationary Phase Chirality 2008, 20(2), 147-150.

7. Zhe Xu, Wenwei Xi, Hua He, Lirui Pan, Xu Xu* Direct Chiral Resolution and its Application to the Determination of the Pesticide Tetramethrin in Soil by High-Performance Liquid Chromatography Using Polysaccharide-Type Chiral Stationary Phase Journal of Chromatographic Science 2008, 46(9), 783-786.