MingLiu

EDUCATION:

2003.9- 2008.7 M.D. Ocean University of China, Roskilde University of Denmark,1999.9-2003.7 B.S.Ocean University of China,

WORK HISTORY:

2008.7- 2011.12Research Associate Institute of Oceanology, Chinese Academy of Sciences

2012.1- 2013.11 Associate ProfessorInstitute of Oceanology, Chinese Academy of Sciences

2013.11- present Associate Professor School of Medicine and Pharmacy, Ocean University of China

RESEARCH AREAS:

Anticancer activity and the mechanisms of marine-derived compounds

GRANTS IN CHARGE:

National Natural Science Foundation of China (81001396)，2011.1-2013.12

National Innovative Drugs Development program of China(2009ZX09102-240)2009.1-2012.12

Open Research Fund Program of Key Laboratory of Marine Drugs (KLMD(OUC)201308), 2013.1-2014.12

RECENT PUBLICATIONS:

1. Liu M, Zhao X, Xiao lin, Liu Ge, Liu H, Wang X, Feng X, Lin X*. Cytotoxicity of the compounds isolated from Pulsatilla chinensis (Bunge) Regel saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm Biol, 2014,Early Online: 1–9 ( DOI:10.3109/13880209.2014.907323).

2. Liu G, Liu M*, Wei J, Huang H, Zhang Y, Zhao J, Xiao L, Wu N, Zheng L, Lin X*. CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting VEGF and MMPs. Mar Drugs, 2014, 12(3):1530-44.

3. Zhao J, Wei J, Liu M*, Xiao L, Wu N, Liu G, Huang H, Zhang Y, Zheng L, Lin X*. Cloning, characterization and expression of a cDNA encoding a granulin-like polypeptide in Ciona savignyi. Biochimie. 2013, 95(8):1611-9.

4. Liu M, Yin H, Dong J, Xiao L, Liu G, Qian Z, Miao J. Inhibition and Interaction with Hyaluronidase by Compounds from Hop (Humulus lupulus L) Flowers. AsianJ Chem 2013, 25(18), 10262-10266.

5. Qiu L, Liu M* and Pan K *. A Triple Staining Method for Accurate Cell Cycle Analysis Using Multiparameter Flow Cytometry. Molecules. 2013, 18(12), 15412-15421.

6. Liu M, Zhao X, Zhao J, Xiao L, Liu H, Wang C, Cheng L, Wu N, Lin X. Induction of apoptosis, G0/G1 phase arrest, and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus. Mar Drugs, 2012, 10(11), 2596-2607.

7.Liu M, Zhang W, Wei J, Lin X. Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro. Toxicol Lett, 2012, 211(2):126-134.

8. Liu M, Wei J, Wang H, Ding L, Zhang Y, Lin X. Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase. Chin. J. Oceanol. Limnol. 2012, 30(5):724-730.

9.Lin X, Liu M*. Bromophenols from Marine Algae with Potential Anti-diabetic Activities. J. Ocean Univ. China. 2012, 11(4):533-538.

10. Liu M, Hansen PE, Lin X. Bromophenols in marine algae and their bioactivities. Mar Drugs. 2011,9(7):1273-92.

11.Liu M, Zhang W, Qiu L, Lin X. Synthesis of butyl-isobutyl-phthalate and its interacition with α–glucosidase in vitro, J Biochem. 2011, 149(1):27-33.

12. Liu M, Zhang W, Wei J, Lin X. Synthesis and α-glucosidase inhibitory mechanisms of bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor. Mar Drugs 2011, 9(9), 1554-1565.