PROFESSIONAL EXPERIENCE

2013.12- date: Professor, Ocean University of China.

2009.9-2013.12: Associate professor, Ocean University of China.

2007-2009: Post Doctoral Research Fellow (Raymond J Andersen group), University of British Columbia.

EDUCATION

2002-2007: PhD, Ocean University of China.

Area of research: Marine Natural products chemistry

Advisors: Professors Qianqun Gu and Weiming Zhu

1998-2002: B.Sc., Shandong University

Major: Pharmacy

RESEARCH

Our research including: 1) the isolation and identification of fungi and actinomycetes from special marine enviroments such as deep-sea, Antarctic, marine biologies, etc; 2) searching for secondary metabolites with bioactivities including antitumor, antifungi, antivirus, etc, from derived microorganisms; 3) expanding the chemical space of secondary metabolites by biosynthesis, metabolic regulationand/or other comprehensive methods; 4) structural modification of bioactive compounds using semi- or total synthesis.

Selected Publications (2010-date):

1.Jixing Peng, Xiaomin Zhang, Lin Du, Wei Wang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Sorbicatechols A and B, Antiviral Sorbicillinoids from the Marine-Derived Fungus Penicillium chrysogenum PJX-17. J. Nat. Prod. 2014, 77(2):424-428

2. Guangwei Wu, Xinhua Sun, Guihong Yu, Wei Wang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Cladosins A−E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum. J. Nat. Prod. 2014,77 (2): 270–275

3. Xinhua Ma, Letao Li, Tianjiao Zhu, Mingyu Ba, Guoqiang Li, Qianqun Gu, Ying Guo* and Dehai Li*. Phenylspirodrimanes with Anti-HIV Activity from the Sponge-derived Fungus Stachybotrys chartarum MXH-X73. J. Nat. Prod. 2013, 2013, 76(12): 2298–2306.

4. Wenqiang Guo, Jixing Peng, Tianjiao Zhu, Qianqun Gu, Robert A. Keyzers,and Dehai Li*. Sorbicillamines A-E, Nitrogen Containing Sorbicillinoids from the Deep-sea Derived Fungus Penicillium sp. F23-2. J. Nat. Prod. 2013, 76(11):2106-2112.

5. Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurtán, Attila Mándi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu and Dehai Li*. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated Fungus Alternaria sp. JJY-32. J. Nat. Prod. 2013, 76, 1946–1957.

6. Jixing Peng, Tao Lin, Wei Wang, Zhihong Xin,* Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Antiviral Alkaloids Produced by the Mangrove-Derived Fungus Cladosporium sp. PJX-41. J. Nat. Prod. 2013, 76(6): 1133-1140.

7. Huquan Gao, Lina Zhou, Shengxin Cai, Guojian Zhang, Tianjiao Zhu, Qianqun Guand DehaiLi*. Diorcinols B-E, new prenylated diphenyl ethers fromthe marine-derived fungus Aspergillus versicolorZLN-60. J. Antibiot. 2013, 66: 539-542.

8. Guangwei Wu, Aiqun Lin, Qianqun Gu, Tianjiao Zhu* and Dehai Li*. Four new chloro-eremophilane sesquiterpenes from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1.Mar. Drugs,2013, 11:1399-1408

9. Shengxin Cai, Yepeng Luan, Xianglan Kong, Tianjiao Zhu, Qianqun Gu,and Dehai Li*. Isolation and photoinduced conversion of 6-epi-Stephacidins from Aspergillus taichungensis.Org. Lett. 2013, 15(9): 2168-2171

10. Qian Che, Tianjiao Zhu, Robert A. Keyzers, Xiaofang Liu, Jing Li, Qianqun Gu, and Dehai Li*. Polycyclichybrid isoprenoids from a reed rhizosphere-soil derived Streptomyces sp. CHQ-64. J. Nat. Prod. 2013, 76(4): 759-763

11. Huquan Gao, Wenqiang Guo, Qiang Wang, Lianqing Zhang, Meilin Zhu, Tianjiao Zhu, Qianqun Gu, Wei Wang*, Dehai Li*. Aspulvinones from a Mangrove Rhizosphere Soil-derived Fungus Aspergillus terreus Gwq-48 with Anti-influenza A viral (H1N1) Activity. Bioorg. Med. Chem. Lett., 2013, 23:1776-1778.

12. Huquan Gao, Weizhong Liu,Tianjiao Zhu, Xiaomei Mo, Attila Mándi,Tibor Kurtán,* Jing Li,* Jing Ai, Qianqun Gu, andDehai Li*.Diketopiperazine Alkaloids from a Mangrove Rhizosphere Soil Derived Fungus Aspergillus effuses H1-1.Org. Biomol. Chem.,2012, 10(47):9501-9506.

13. Guangwei Wu,Hongyan Ma,Tianjiao Zhu,Jing Li,Qianqun Gu, and Dehai Li*. Penilactones A and B, Two Novel Polyketides from Antarctic Deep-sea Derived Fungus Penicillium crustosum PRB-2. Tetrahedron. 2012, 68 (47): 9745–9749.

14. Qian Che, Tianjiao Zhu, Xin Qi, Attila Mándi, Tibor Kurtán, Xiaomei Mo, Jing Li,Qianqun Gu, and Dehai Li*. Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64. Org. Lett. 2012, 14(13): 3438-3441.

15. Liyuan Li, Dehai Li, Yepeng Luan, Qianqun Gu and Tianjiao Zhu*.Cytotoxic metabolites from theantarctic psychrophilic fungus Oidiodendron truncatum. J. Nat. Prod. 2012, 75(5): 920-927.

16. Jixing Peng, Jieying Jiao, Jing Li, Wei Wang, Qianqun Gu, Tianjiao Zhu*, DehaiLi*. Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40. Bioorg. Med. Chem. Lett., 2012, 22(9): 3188-3190.

17. Shengxin Cai, Xianglan Kong, Wei Wang, Huinan Zhou, Tianjiao Zhu, DehaiLi*, Qianqun Gu*. Aspergilazine A, a Diketopiperazine Dimer with a Rare N-1 to C-6 Linkage,from a Marine-derived Fungus Aspergillus taichungensis. Tetrahedron. Lett.. 2012, 53 (21): 2615-2617.

18. LiChen, TianjiaoZhu, Yuanqing Ding, Ikhlas A. Khan*, Qianqun Gu, and DehaiLi*. Sorbiterrin A, a novel sorbicillin derivative with cholinesterase inhibition activity from the marine-derived fungus Penicillium terrestre. Tetrahedron. Lett.. 2012,53(3): 325-328.

19. Dehai Li, Li Chen, Tianjiao Zhu, Tibor Kurtán,* Attila Mándi, Zhimin Zhao, Jing Li,* and Qianqun Gu*. Chloctanspirones A and B, novel chlorinated polyketides with an unprecedented skeleton, from marine sediment derived fungus Penicillium terrestre. Tetrahedron.. 2011, 67 (41): 7913-7918.

20. Lin Du, Hongchun Liu, Wei Fu, Dehai Li, Qiuming Pan, Tianjiao Zhu, Meiyu Geng*, and Qianqun Gu*. Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase Iiα inhibitor. J. Med. Chem. 2011, 54, 5796-5810.

21. GuojianZhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li* and Qianqun Gu*. Antiviral isoindolone derivatives from an endophytic fungus Emericella sp.associated with mangroveAegiceras corniculatum. Phytochemestry. 2011, 72, 1436-1442.

22. Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao and Qianqun Gu*. New Cytotoxic Metabolites from a Deep-Sea-Derived Fungus, Phialocephala sp., Strain FL30r. Chem. Biodivers. 2011, 8(5): 895-901.

23. Dehai Li, Gavin Carr, Yonghong Zhang, David E. Williams, Ashraf Amlani, Helen Bottriell, Alice L.-F. Mui, and Raymond J. Andersen*. Turnagainolides A and B, Cyclic Depsipeptides Produced in Culture by a Bacillus sp. Isolation, Structure Elucidation, and Synthesis.J. Nat. Prod. 2011, 74(5): 1093-1099.

24. Shengxin Cai, Shiwei Sun, Huinan Zhou, Xianglan Kong, Tianjiao Zhu, Dehai Li*, and Qianqun Gu*. Prenylated polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07. J. Nat. Prod., 2011, 74(5): 1106-1110.

25. Lin Du, Jing Ai, Dehai Li, Tianjiao Zhu, Ying Wang, Michael Knauer, Torsten Bruhn, Hongbing Liu, Meiyu Geng,* Qianqun Gu,* and Gerhard Bringmann*, Aspergiolides C and D, Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects.Chem-Eur.J, 2011, 17(4), 1319-1326.

26. Lin Du, Dehai Li, Guojian Zhang, Tianjiao Zhu, Jing Ai, Qianqun Gu. Novel carbon-bridged citrinin dimers from a volcano ash-derived fungusPenicillium citrinumand their cytotoxic and cell-cycle arrest activities.Tetrahedron.2010, 66: 9286-9290.

27. Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, and Qianqun Gu. Three new sorbicillin trimers, trisorbicillinones B, C and D, from a deep ocean sediment derived fungus, Phialocephala sp. FL30r. Tetrahedron.. 2010, 66(27-28): 5101-5106.