Chang-Lun Shao
Ph.D., Professor of Medicinal Chemistry
Education:
1. Ph.D. in Organic Chemistry (Co-funded by Syngenta Doctoral Fellowship, United Kingdom): Sun Yat-sen University at Guangzhou, China, 2002–2007. Supervisors: Prof. Yongcheng Lin and Prof. Yucheng Gu
2. B.S. in Chemistry: Qufu Normal University at Qufu, China, 1998–2002
Positions and Employment:
2014.1– Professor of Medicinal Chemistry, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
2011.1–2013.12 Associate Professor of Medicinal Chemistry, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
2011.11–2013.12 Visiting Professor, Scripps Institution of Oceanography, University of California, San Diego, USA (Prof. William H. Gerwick Laboratory)
2007.7–2010.12 Lecturer, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
Research Interests:
1. Isolation and structure elucidation of marine bioactive natural compounds from soft corals and gorgonian corals as well as their symbiotic microorganisms collected from the South China Sea.
2. Evaluation of the relationships based on secondary metabolites between marine invertebrates and their symbiotic microorganisms in the areas of marine chemical ecology, biosynthesis, and chemical taxonomy.
3. Assessment the possible relationships between the pharmacological effects (such as cytotoxic, antiviral, antifungal and antibacterial activities) and the chemoecological functions (such as toxicity, allelopathy, ichthyotoxic, antifeeding and antifouling activities).
Current Research Support:
1. Marine Medicinal Bioresources. The National Natural Science Foundation of Chinafor Excellent Young Scholars (No.41322037, 2014.01–2016.12). (Shao CL, PI)
2. Research on the secondary metabolites and their antifouling activity of two gorgonian coralsAnthogorgia caerulea andAnthogorgia ocbracea and theirsymbiotic microorganisms. The project of National Natural Science Foundation of China (No.41176121, 2012.01–2015.12). (Shao CL, PI)
3. New Century Excellent Talents in University. The Ministry of Education of China (2012.01–2014.12). (Shao CL, PI)
4. Chemical defensive substances from gorgonian coral Dichotella gemmacea and their symbiotic microorganismscollected from the South China Sea and their anti-tumor effects. The National Natural Science Foundation of China for young Scholars (No.30901879, 2010.01–2012.12). (Shao CL, PI)
5. Chemical defensive substances and their chemoecological effects of marine medicinal organisms from the coral reef ecosystem. The Key Program of National Natural Science Foundation of China (No.41130858, 2012.01–2016.12). (Wang CY, PI, Shao CL, co-PI)
Selected Publications:
1. Chang-Lun Shao,Ru-Fang Xu, Mei-Yan Wei,Zhi-Gang She*, Chang-Yun Wang*. Structure and Absolute Configuration of Fumiquinazoline L, anAlkaloid from a Gorgonian-Derived Scopulariopsis sp. Fungus. J. Nat. Prod., 2013, 76, 779–782.
2. Kai-Lin Yang, Mei-Yan Wei, Chang-Lun Shao*, Xiu-Mei Fu, Zhi-Yong Guo, Ru-Fang Xu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin, Chang-Yun Wang*. Antibacterial Anthraquinone Derivatives from a Sea Anemone-Derived Fungus Nigrospora sp. J. Nat. Prod., 2012, 75(5), 935–941.
3. Dan Li, Ying Xu, Chang-Lun Shao*, Rui-Yun Yang, Cai-Juan Zheng, Yi-Yan Chen, Xiu-Mei Fu, Pei-Yuan Qian, Zhi-Gang She, Nicole J. de Voogd, Chang-Yun Wang*. Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp. Mar. Drugs 2012, 10, 234-241.
4. Chang-Lun Shao, Hui-Xian Wu, Chang-Yun Wang*, Qing-Ai Liu, Ying Xu, Mei-Yan Wei, Pei-Yuan Qian, Yu-Cheng Gu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin. Potent Antifouling Resorcylic Acid Lactones from the Gorgonian-Derived Fungus Cochliobolus lunatus, J. Nat. Prod. 2011, 74(4), 629–633.
5. Chang-Lun Shao, Chang-Yun Wang*, Mei-Yan Wei, Yu-Cheng Gu, Zhi-Gang She*, Pei-Yuan Qian, Yong-Cheng Lin. Aspergilones A and B, Two Benzylazaphilones with an Unprecedented Carbon Skeleton from the Gorgonian-Derived Fungus Aspergillus sp. Bioorg. Med. Chem. Lett. 2011, 21(2), 690–693.
6. Chang-Lun Shao, Chang-Yun Wang*, Yu-Cheng Gu,Mei-Yan Wei,Jia-Hui Pan,Dong-Sheng Deng,Zhi-Gang She*, Yong-Cheng Lin*. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg. Med. Chem. Lett.2010, 20(11), 3284-3286.
7. Mei-Yan Wei, Chang-Yun Wang*, Qing-Ai Liu, Chang-Lun Shao*, Zhi-Gang She, Yong-Cheng Lin. Five Sesquiterpenoids from a Marine-Derived Fungus Aspergillus sp. Isolated from a Gorgonian Dichotella gemmacea. Mar. Drugs 2010, 8, 941-949.
Address:
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China.
Tel: +86-532-82031381;
Fax: +86-532-82031503.
E-mail: shaochanglun@ouc.edu.cn.
