Individual Resume:
Dr. Tao Jiang, female, Professor, Doctoral Supervisor, winner of outstanding youths awards of Chinese Ministry of Education, editorial board member of journal of Fine Chemicals, reviewer of E. J. Med. Chem., Bioorg. Med. Chem., Tetrahedron, etc.
Dr. Jiang was graduated in 1993 for her doctoral degree from Changchun Institute of applied Chemistry, Chinese Academic of Sciences. After that she studied in Hong Kong Baptist University for her post-doctoral training from Nov. 1993 to Nov. 1995， then worked with the department of Chemistry and Biological Sciences, University of Essex in UK as visiting scientist for one year. She joined the Marine Drug and Food Institute of Ocean University of China in 1997 and became a professor in medicinal chemistry in Dec. 1997, a doctoral supervisor in 2001. During Nov. to Dec., 2004, she worked in Lady Davis Institute, Jewis General Hospital in Canada for cooperative research.
Dr. Jiang has designed and synthesized a series of nucleic acid intercalating agents as well as shear agents, accomplished syntheses, structure optimization and SAR studies of various marine natural heterocyclic alkaloids. She has also performed drug design, syntheses and bioactivity research based on saccharous structure. A variety of compounds are undertaking candidate drugs or preclinical research. She has lead and took 23 research projects, assigned 4 projects. Now she is conducting 1 international cooperative project of Chinese Ministry of Science and Technology, 2 projects of Natural Science Foundation of China and several other projects. 3.56 million RMB as research funds has been forthcoming up to now. She has published over 70 papers on Chem. Comm., J. Med. Chem., E. J. Med. Chem., Bioorg. Med. Chem. and other journals, applied 12 national patents for invention, among which 4 have been authorized.
Contact Information:
Tel: 0532-82032712； Fax: 0532-82033054；Email: jiangtao@ouc.edu.cn
Postal Address:
Key laboratory of marine drug of Chinese Ministry of Education,
School of Medicine and Pharmacy,
Ocean University of China,
No.5 Yushan Road,
Qingdao, Shandong Province, 266003.
Enrollment and Training of Graduate Students:
Major: Medicinal Chemistry ＆ Pharmaceutical Engineering
15 doctors and 22 masters have graduated from our lab, and there are currently 6 doctor candidates and 10 master candidates in our lab. Graduates from our lab are mainly engaged in drug research and teaching, among which three have been promoted to the senior management layers of their companies.
Major Research Areas: Drug Design and Syntheses
1. Syntheses, structural optimization and SAR studies of marine natural products such as marine heterocylic alkaloids;
2. Chemical modification including glycosylation and phosphate esterification of bioactive molecules, and drug design and syntheses based on saccharous structure.
Recent Scientific Projects:
1. International cooperative key projects of Chinese Ministry of Science and Technology (2013DFG32160);
2. Natural Science Foundation of China (reference number: 21171154);
3. Natural Science Foundation of China (reference number: 81373322);
Recent Publications:
1. Exploring pyrimidine-substituted curcumin analogues: Design, synthesis and effects on EGFR signaling, Peiju Qiu , Lingling Xu , Lei Gao, Meng Zhang, Shixi Wang, Sheng Tong, Yue Sun, Lijuan Zhang*, Tao Jiang*, Bioorganic & Medicinal Chemistry 21 (2013) 5012–5020.
2. Different cytotoxicities and cellular localizations of novel quindoline derivatives with or without boronic acid modifications in cancer cells, Ruijuan Yin, Meng Zhang, Cui Hao, Wei Wang, Peiju Qiu, Shengbiao Wan, Lijuan Zhang* and Tao Jiang*, ChemComm, (2013), Cite this: DOI: 10.1039/c3cc45203d
3. Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid, Jiuyang Zhao, Wei Li, Rui Ma, Shaopeng Che, Sumei Ren and Tao Jiang *, Int. J. Mol. Sci. 2013, 14, 16851-16865; doi:10.3390/ijms140816851
4. Total Synthesis and Biological Activity of Marine Alkaloid Eudistomins Y1–Y7 and Their Analogues, Huijuan Jin, Puyong Zhang, Krikor Bijian, Sumei Ren, Shengbiao Wan, Moulay A. Alaoui-Jamali,* and Tao Jiang,* Mar. Drugs 2013, 11, 1427-1439; doi:10.3390/md11051427
5. Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases， Krikor Bijian, Zhongwei Zhang, Bin Xu, Su Jie, Bo Chen, Shengbiao Wan, JianHui Wu b, Tao Jiang*, Moulay A. Alaoui-Jamali* Eur. J. Med. Chem., 48 (2012) 143-152
6. Synthesis, Saccharide–Binding, and Anti-cancer Cell Proliferation Properties of Arylboronic Acid Derivatives of Indoquinolines, Jun-xiuMeng, Shao-qing Yu, Sheng-biao Wan, Su-mei Ren, Tao Jiang* Chem. Biol. Drug Des., 2011,78:816-825（SCI IF=2.52）
7. Design and Synthesis of a Series of Novel Bisquinazoline Glycosides as Epidermal Growth Factor Receptor Inhibitors, Shaopeng Chen, Xiaowei Zhang, Junlei Wang, Shengbiao Wan, Meiyu Geng,* and Tao Jiang* Chem Biol Drug Des, 2011,78:1006-1013.
