Research Contents

Aiming at critical illnesses such as tumor, diabetes and neurodegeneration diseases, and focusing on officinal small molecules, carbohydrates and coordination complexes of natural products (especially marine natural products) which possess bioactivities, we perform chemical syntheses, molecular design, structural modification and structure-activity relationship (SAR) studies through computer-assisted drug design (CADD) and combinatorial chemistry techniques to provide theoretical foundation and candidate compounds for the research and development of innovative drugs.

Research Areas

u Syntheses and SAR of such (marine) natural products as alkaloids and bioactive peptides

u Syntheses and SAR of oligosaccharides and glycoconjugates

u Glycosylation modification of bioactive molecules

u Novel glycosylation reactions and synthetic strategies

u Design, syntheses and bioactivities of novel inorganic drugs

u Design, syntheses and bioactivities of novel metal-glyco complexes

Research Team

u Yantuan Li, Professor and Doctoral Supervisor (more information)

u Tao Jiang, Professor and Doctoral Supervisor (more information)

u Shengbiao Wan, Associate Professor and Master’s Supervisor (more information)

u Ming Li, Associate Professor and Master’s Supervisor (more information)

u Zhiyong Wu, Associate Professor and Master’s Supervisor (more information)

u Yankai Liu, Associate Professor

u Peng Wang, Lecturer

Enrolled graduate students in 2013: 18 Doctoral Candidates and 30 Master Candidates;

Graduated students up to 2013: 20 Doctors and 30 Masters.

Major Achievements

We have accomplished 8 projects of national “863”, Natural Science Foundation of China and “973” subprojects in recent years, and now we are taking over 10 State-level projects of “863” and international cooperation. We have made prominent achievements in the syntheses and SAR research of glycoconjugates, glycocomplexes and marine natural products.

u Accomplished total syntheses of over 10 bioactive natural products

u Obtained 4 highly active anti-tumor compounds

u Taking systematically preclinical research on 2 candidate drugs

u Published papers on SCI journals including, such as ChemComm, J. Med. Chem., J. Inorg. Biochem., J. Coord. Chem., Chem. Biol. Drug Des., and Carbohydr. Res.. Authorized 8 patents.