Laboratory of Molecular Medicine (LMM) was established in 2005. Both Professor Huashi Guan (the former president of OUC) and so on are honor directors of LMM. Research areas in the LMM include 1) basic biology of molecular medicine; 2) roles of biomolecules in regulating development, growth, reproduction, and aging; 3) establishment of animal models of human disease; 4) chemical biology and compound screening by using zebrafish. Research in the LMM is supported by NSFC and MOST. 

Members:

Yun Li, professor

Jianfeng Zhou, professor

Ling Lu, associate professor

Yunzhang Liu, engineer

Recent Publications

Zhou J., Xiang J., Zhang S., and Duan C. (2013) Structural and functional analysis of the amphioxus IGFBP gene uncovers ancient origin of IGF-independent functions.

Endocrinology. 154(10):3753-63.

Liu C., Luan J., Bai Y., Li Y., Lu L., Liu Y., Hakuno F., Takahashi S.I., Duan C., and Zhou J. (2013). Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos. General and Comparative Endocrinology. 2013 Dec 19. pii: S0016-6480(13)00480-2. doi: 10.1016/j.ygcen.2013.12.006. [Epub ahead of print]

Feng Q., Zou X., Lu L., Li Y., Liu Y., Zhou J. and Duan C. (2012). The Stress-response gene redd1 regulates dorsoventral patterning by antagonizing wnt/b-catenin activity in zebrafish. PLoS ONE, e52674.

Zhang P., Lu L., Yao Q., Li Y., Zhou J., Liu Y., and Duan C. (2012). Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303, R1165-R1174.

Zhang, C., Lu, L., Li, Y., Wang, X., Zhou, J., Liu, Y., Fu, P., Gallicchio, M. A., Bach, L. A., Duan, C. (2012). IGF binding protein‐6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. International Journal of Cancer, 130(9), 2003-2012

Zhong, Y., Lu, L., Zhou, J., Li, Y., Liu, Y., Clemmons, D. R., Duan, C. (2011). IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. Journal of Cell Science, 124(11), 1925.

Jiao, S., Dai, W., Lu, L., Liu, Y., Zhou, J., Li, Y., Korzh, V., Duan, C. (2011). The Conserved Clusterin Gene Is Expressed in the Developing Choroid Plexus Under the Regulation of Notch But Not IGF Signaling in Zebrafish. Endocrinology, 152(5), 1860.

Li, M.Y., Li, Y., Lu, L., Wang, X.L., Gong, Q.L., and Duan, C. (2009). Structural, gene expression, and functional analysis of the Fugu (Takifugu rubripes) IGF binding protein-4 gene. Am. J. Physiol. 296: R558 - R566.

Wang, X.L., Lu, L., Li, Y., Li, M.Y., Chen, C., Feng, Q., Zhang C.Y., and Duan, C.  (2009). Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. Am J Physiol Regul Integr Comp Physiol, 296(5):R1348-1357.

Zhou J, Li W, Kamei H, Duan C. (2008). Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS One, 3(12):e3926.