Yankai Liu, PhD, Associate Professor
Laboratory of Marine Drugs
School of Medicine and Pharmacy, Ocean University of China (OUC)
No.5, Yushan Rd., Qingdao 266003
P. R. China
Phone: 86-181053210029;
E-mail: cd_yankai@163.com or cd.yankai@gmail.com
Education:
1998.09-2002.07, B.Sc., Shandong University of Medical Sciences, Medicinal Chemistry
2004.09-2006.07, M.Sc., Sichuan University, Medicinal Chemistry
2006.09-2009.08, Ph.D, Sichuan Universit, Organic Chemistry and Medicinal Chemistry
2009.09-2009.12, Exchange student, University of Cologne, Organic Catalysis and Synthesis
Working background:
2002.08-2004.09, Researcher, Research & Development Institute, Hendian Group Co. Ltd
2010.04-2012.11, Postdoc, ICIQ in Spain, Organic Catalysis and Synthesis
2012.12-2013.09, Associate Professor, Southwest Jiaotong University
2013.10-, Associate Professor,Ocean University of China
Teaching:
2014.03-, Medicinal Chemistry, for undergraduate students
Research Interests:
Asymmetric Orgnaocatlysis in the Synthesis of Chiral Structure
Modification of Marin Drugs with Asymmetric Orgnaocatlysis
Fine structural studies of Marin drugs
Awards:
Marie Curie fellowship, 2011
Research Projects:
Studies on asymmetric catalysis reactions via aza-dienamine or aza-trienamine activation, National Natural Science Foundation of China (No. 21302156), 250,000¥, 2014.01-2016.12
Asymmetric organocatalysis in the synthesis of marine drugs, Ocean University of China, 200.000¥, 2014.01-2016.12
Selected Publications:
1）David Bastida, Yankai Liu, Xu Tian, Eduardo Escudero-Adán, and Paolo Melchiorre*, “Asymmetric Vinylogous Aldol Reaction via H-Bond-Directing Dienamine Catalysis”, Org. Lett., 15(1),220-223, 2013
2）Xu Tian, Yan-kai Liu, Paolo Melchiorre*, “Aminocatalytic Enantioselective 1,6-Additions of Alkyl Thiols to Cyclic Dienones: Vinylogous Iminium Ion Activation”,Angew. Chem. Int. Ed. 51(26), 6439-6422, 2012
3）Yan-Kai Liu, Manuel Nappi, Eduardo C. Escudero-Adán, and Paolo Melchiorre*, “Multicatalytic Asymmetric Synthesis of Complex Tetrahydrocarbazoles via a Diels–Alder/Benzoin Reaction Sequence”,Org. Lett., 14(5), 1310-1313, 2012
4）Yan-Kai Liu, Manuel Nappi, Elena Arceo, Silvia Vera, and Paolo Melchiorre*, “Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclic ortho-Quinodimethanes”, J. Am. Chem. Soc., 133(38), 15212-15218, 2011
5）Xu Tian, Carlo Cassani, Yan-kai Liu, Antonio Moran, Atsushi Urakawa, Patrizia Galzerano, Elena Arceo, Paolo Melchiorre*, “Diastereodivergent Asymmetric Sulfa-Michael Additions of alpha-Branched Enones using a Single Chiral Organic Catalyst”,J. Am. Chem. Soc., 133(44), 17934-17941, 2011
6）Silvia Vera, Yan-kai Liu, Mauro Marigo, Eduardo C. Escudero-Adán, Paolo Melchiorre* “Asymmetric Michael Additon of Nitrobenzyl Pyridines to Eanals under Iminium Catalysis”,Synlett., 2011(4), 489-494, 2011
7）Hailei Cui, Kun Jiang, Yan-Kai Liu, Wei Du, Yingchun Chen,* “Enantioselective direct aldol-type reaction of 4-hydroxycoumarin with ethyl trifluoropyruvate catalyzed by modified cinchona alkaloids”,Chin. Sci. Bull., 55(17), 1732-1734, 2010
8）Yan-Kai Liu, Chao Ma, Kun Jiang, Tian-Yu Liu, and Ying-Chun Chen*, “Asymmetric Tandem Michael Addition-Wittig Reaction to Cyclohexenone Annulation”,Org. Lett., 11(13), 2848-2851, 2009
