Li Chunxia, PhD, Professor
Laboratory of Glycoscience and Glycotechnology
School of Medicine and Pharmacy
Ocean University of China
5 Yushan Road, Qingdao 266003, P. R. China
Tel: +86-532-82032030(Office);Fax: 86-532-82033054
Email: lchunxia@ouc.edu.cn
Education:
1997.092002.07:PhD in Medicinal Chemistry, Marine Drugs and Food Institute, Ocean University of Qingdao, P. R. China (Advisor Prof.Huashi Guan and Prof. Yingxia Li).
1993.09-1997.07:B.S.in Food Science and Engineering, Ocean University of China, P. R. China.
Professional Experience：
2014.01-Present:Professor of Medicinal Chemistry, School of Medicine and Pharmacy, Ocean University of China
2006.012014.01:Associate Professor of Medicinal Chemistry, School of Medicine and Pharmacy, Ocean University of China
2008.09-2009.09:Visiting Scholar, Complex Carbohydrate Research Center (CCRC), University of Georgia, USA
2002.07-2005.12: Lecturer of Medicinal Chemistry, School of Medicine and Pharmacy, Ocean University of China
Teaching:
2002-Present: Identification of Organic Compounds by Spectroscopy, for undergraduate students
2011-Present: Medicinal Chemistry, for undergraduate students
2010-2011: Stereochemistry of Organic Compounds, for Graduate students
2011-Present:Structure and Function of Glycoconjugates (carbohydrate chemistry), for Graduate students
Research Interests:
1. Carbohydrate Chemistry and Carbohydrate-based Drugs: Chemical syntheses of bioactive glycosides and oligosaccharides and study on their functions; Isolation, modification and synthesis of marine oligosaccharides, such as chitooligosaccharides, oligomannuronates and oligofucans for bioactivity evaluation; Development of novel methodology for the synthesis of carbohydrate-containing structures.
2. Marine Natural Product Chemistry: Synthesis of marine natural products with pharmacological activity and their structural optimization for drug candidate development, such as glycolipids and peptides.
Research Projects:
1. The synthesis of glycolipid inhibitors of Myt1 kinase and the research of their structure-activity-relationship, National Natural Science Foundation of China (NSFC) (No. 81072574), 01/01/2011-12/31/2013,PI Chunxia Li.
2. Screening of biological activities of fucoidans from Chinese brownalgae and studies of their dependence on structural characteristics, International Collaboration exchange Program of NSFC-RFBR (No. 81311120092), 01/01/2013-12/31/2014, PI Chunxia Li.
3. The research and formulation of new quality standards of marine drug--PSS, Qingdao Science and Technology Project (No. 11-2-3-73-jh), 10/01/2011-09/30/2013,PI Chunxia Li.
4. The research and development of marine drug--new PSS, Shandong Science and Technology Project (2011GSF11815), 12/31/2011-09/30/2012,PI Chunxia Li.
5. The Program for New Century Excellent Talents in University (No. NCET-08-0506), 01/01/2009-12/31/2011, PI Chunxia Li.
6. The scale preparation techniques of marine bioactive peptides and the acquisition of antitumor lead compounds, National High-Tech R&D Program (863 Program of China (2006AA09Z409), 12/01/2006-12/01/2009, PI Chunxia Li.
7. The research of the semi-synthesis of ursolic acid saponins and their anticancer activity,the National Natural Science Foundation of China (NSFC) (No. 30400564), RMB230,000, 01/01/2005-12/31/2007,PI Chunxia Li.
8. The synthesis of marine natural peptide-Obyanamide and its analogues and the research of their structure-activity relationship, theExcellent Young Scientists Foundation of Shandong Province (No. 2006BS02013), 11/01/2006-11/31/2008,PI Chunxia Li.
Selected Publications:
1. Jun Zhang, Chunxia Li *, Guangli Yu and Huashi Guan, Total Synthesis and Structure-Activity Relationship of Glycoglycerolipids from Marine OrganismsMar. Drugs,2014, 12, 3634-3659
2. Shan He, Jiejie Hao,Weibing Peng, Peiju Qiu, Chunxia Li*, Huashi Guan*, Modulation of lipid metabolism by Deep-sea Water in cultured human liver (HepG2) cells, Mar Biotechnol, 2014, 16, 219-229
3. Jian Wu, Xia Zhao*, Li Ren, Yiting Xue, Chunxia Li, Guangli Yu, Huashi Guan, Determination of M/G ratio of propylene glycol alginate sodiumsulfate by HPLC with pre-column derivatization, Carbohydr Polym, 2014, 104, 23-28
4. Peng-Li Li, Chun-Xia Li*, Yi-Ting Xue, Hai-Hua Li, Hong-Bing Liu, Xiao-Xi He, Guang-Li Yu and Hua-Shi Guan, An HPLC Method for Microanalysis and Pharmacokinetics of Marine Sulfated Polysaccharide PSS-Loaded Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles in Rat Plasma,Mar Drugs,2013, 11, 1113-1125
5. Quancai Li, Chunxia Li*, Cheng Yang, Chenchang Liu, Guangli Yu, Huashi Guan, Preparation,characterization and antioxidant activities of polymannuronic phosphate,H-phosphonate and sulfate, Int J Biol Macromol, 2013, 62, 281-286
6. Jun Zhang,Yihua Sun, Chunxia Li*, Wei Wang, Xiaoshuang Zhang,Huashi Guan,Synthesis and antiviral evaluation of 6'-acylamido-6'-deoxy-α-D-mannoglycerolipids, Carbohydr Res, 2013, 381,74-82
7. Chunxia Li*,Yihua Sun, Jun Zhang, Zhimin Zhao, Guangli Yu, Huashi Guan,Synthesis of 6'-acylamido-6'deoxy-α-D-galactoglycerolipids, Carbohydr Res, 2013, 376, 15-23
8. Ting Hu, Chunxia Li, Xia Zhao*, Guangsheng Li, Guangli Yu, Huashi Guan, Preparation and characterization of guluronic acid oligosaccharidesdegraded by a rapid microwave irradiation method, Carbohydr Res,2013, 373, 53-58
9. Yihua Sun, Jun Zhang, Chunxia Li*, Huashi Guan, Guangli Yu, Synthesis of glycoglycerolipid of 1,2-dipalmitoyl-3-(N-palmitoyl-6'-amino-6'-deoxy-a-D-glucosyl)-sn-glycerol and its analogues, inhibitors of humanMyt1-kinase, Carbohydr Res,2012, 355, 6-12
10. Thomas J. Boltje, Chunxia Li, Geert-Jan Boons*,Versatile Set of Orthogonal ProtectingGroups for the Preparation of HighlyBranched Oligosaccharides, Org Lett, 2010, 12 (20), 4636-4639
11. Wu Haijun, Li Chunxia, Song Gaopeng, Li Yingxia*, Synthesis of Natural a-6-Dehydroxy-6-aminoglucoglycerolipids, Chin J Chem, 2008, 26, 1641-1646.
12. Zhenhua Ma, Ni Song, Chunxia Li, Wei Zhang, Peng Wang and Yingxia Li*, Total synthesis and stereochemical reassignment of tasiamide, J Peptide Sci, 2008, 14, 1139-1147
13. Ning Ding, Chunxia Li, Yunpeng Liu, Zaihong Zhang, Yingxia Li*, Concise synthesis of clarhamnoside, a novel glycosphingolipid isolated from the marine sponge Agela clathrodes, Carbohydr Res, 2007, 342, 2003-2013
14. Chunxia Li, Jing Zang, Peng Wang, Xiuli Zhang, Huashi Guan, Yingxia Li*, Synthesis of Two Natural Oleanolic Acid Saponins, Chin J Chem,2006, 24, 509-517
15. Chunxia Li, Tiantian Guo, Peng Wang, Huashi Guan, Yingxia Li*, Semi-synthesis of Several Stigmasterol Saponins, Chin J Chem,2006, 24, 917-922
16. Wei Zhang, Zhenhua Ma, Duo Mei, Chunxia Li, Xiuli Zhang and Yingxia Li*,Total synthesis and reassignment of stereochemistry of obyanamide, Tetrahedron, 2006, 62, 9966-9972
17. Peng Wang, Chunxia Li, Jing Zang, Ni Song, Xiuli Zhang and Yingxia Li*, Synthesis of two bidesmosidic ursolic acid saponins bearing a2,3-branched trisaccharide residue, Carbohydr Res,2005, 340, 2086-2096
18. Yingxia Li*, Chunxia Li, Peng Wang, Shidong Chu, Huashi Guan, and Biao Yu*, An unprecedented N-transacylation reaction on 2-acetamido- 2-deoxy-α-D-glucopyranosides, Tetrahedron Lett,2004, 45, 611-613
