Ming Li

Associate professor,  Principal Investigator of synthetic laboratory I of medicinal chemistry.

Tel: +86-532-82032150

Fax: +86-532-82033054

E-mail:lmsnouc@ouc.edu.cn

Backgroud:

1994-1998Sichuan UniversityBechalor degree

1998-2003Dalian Institute of Chemical Physcs, CASPh. D

2004-2006Shanghai Insitute of Organic Chemistry, CASAssistant researcher

2006-2010University of Illinois at Chicago, USAPostdoctor

2010-    Ocean University of China               Associate professor

Research:

My group concentrates on novel glycosylations in carbohydrate chemsitry and their applications in total synthesis of bioactive glycoconjugates including oligosaccharides, saponins and glycopeptides.

Selected Papers:

1. Chen, P.; Wang, P.; Song, N.; Li, M.* Convergent synthesis of Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin. Steroids, 2013, 78, 959-966.

2. Zhang, Y.; Wang, P.; Song, N.; Li, M.* Bromodimethylsulfonium bromide/silver triflate-promotedglycosylations using glycosyl allenoates as donors. Carbohydr. Res.2013, 381, 101-110.

3. Liu, S.；Peng, Y.; Wang, P.; Li, M.* Glycosyl N-Tosyl benzimidate as a New Building Block for Chemical Glycosylation, Synlett, 2012, 1501-1504 (IF 2.6).

4. Shi, D.; Zhang,W.; Ding,N.; Wang,P.; Li, M.*, Li Y.* Design,synthesis and biological evaluation of novel glycosylated diphyllin. Eur. J. Med. Chem.2012, 47, 424-431.

5. Li, M.; Zengeya, T.;Rozners, E. Short Peptide Nucleic Acids Bind Strongly to Homopurine Tract of Double Helical RNA at pH 5.5.  J. Am. Chem. Soc.2010, 132, 8676-8681(IF 10.8).

6. Crich, D.*; Li, M. Block Synthesis of Tetra- and Hexasaccharides (β-D-Glycero-D-manno-Hepp-(1→4)-[α-L-Rhap-(1→3)-β-D-glycero-D-manno-Hepp-(1→4)]n-α-L-Rhap-OMe (n = 1 and 2)) Corresponding to Multiple Repeat Units of the Glycan from the Surface-Layer Glycoprotein from Bacillus thermoaerophilus. J. Org. Chem.2008, 73, 7003-7010 (Featured Article)(IF 4.8).

7. Crich, D.*; Li, M. Revisiting the Armed-Disarmed Concept: The Importance of Anomeric Configuration in the Activation of S-Benzoxazoyl Glycosides. Org. Lett.2007, 9, 4115-4118(IF 6.2).

8. Li, M.; Yu, B. Facile Conversion of Spirostan into Furostan: Synthesis of Methyl Protodioscin and Its 26-Thio-analogue. Org. Lett.2006, 8, 2679-2682(IF 6.2).

9. Li, M.; Han, X; Yu, B* Facile Synthesis of Flavonoid 7-O-Glycosides.J. Org. Chem. 2003, 68, 6842 – 6845 (IF 4.8).

10. Zengeya, T.; Li, M.; Rozners, E. PNA Containing Isocytidine Nucleobase:Synthesis and Recognition of Double Helical RNA. Bioorg. Med. Chem. Lett.2011, 21, 2121-2124 (IF 2.6).

11. Crich, D.*; Li, M.; Jayalath, P.Synthesis of 4-O-(2-O-phenylmethyl-sulfonyl- β-D-mannopyranosyl)-2-deoxy-2-acetamido-β-D-glucopranoside. Carbohydr. Res.2009, 334, 140-144 (IF 2.0).