Dr. Weiming Zhu, Professor and doctoral supervisor, deputy director of the Key Laboratory of Marine Drugs of Education Ministry of China. He is engaged in the research of Natural Medicinal Chemistry, especially from microorganisms lived in marine and other special habitats. He has identified 400 new compounds from plants and microbial metabolites.He has published more than 190 publications, most of which were published in the SCI journals. These papers had been cited 2023 times. The current H-index of Weiming Zhu is 24.
Tel. 0532-8203126, Fax. 0532-82031268, E-mail: weimingzhu@ouc.edu.cn
Research field:
1.Discovery of new hits and lead compounds of microbial talented strains from marine and other special environments by means of integrated chemical and biological screening methods.
2.Investigation of methods to transformation of non-talented strains into talented strains.
3.Discovery of new drug leads by structural modification of new hits.
Research programs:
1.Study on the algicolous microbes from Enteromorpha prolifera and their allelopathic natural products containing nitrogen and halogen atoms (NSFC, No. 41376148, 2014–2017).
2.Maximizing chemical diversity of marine fungal metabolites by environmental stress (NSFC, No. 21172204, 2012–2015).
3.Discovery and biosynthesis of bioactive compounds from deep sea-derived microorganisms (863 Program of China, No. 2012AA092104-1, 2012–2015).
4.Bioactivity and mechanism of secondary compounds from marine microorganisms (973 Program of China, No. 2010CB833804, 2010–2014).
5.Evaluation of the druggability of HDZ-137 to reverse multidrug resistance of breast cancer (863 Program of China, No. 2011AA09070106, 2011–2014).
Educational background:
1.1981–1985:B.Sc. in Chemistry from Wuhan University.
2.1985–1988: M.S. in Organic Chemistry from Wuhan University.
3.1997–2001: Ph. D. in Natural Products from Kunming Institute of Botany, Chinese Academy of Science.
Employment History:
1.1988–2003: Lecturer, Associated professor and Professor in Departmentof Chemistry, Yunnan Normal University, China.
2.2001–2003: Postdoctoral research in Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science
3.2003–present: Professor in School of Medicine and Pharmacy, Ocean university of China
Selected Publications:
2014
1.Fandong Kong, et al,Weiming Zhu*, Thiodiketopiperazines from the marine-derived fungus Phoma sp. OUCMDZ-1847. J Nat Prod, Article ASAP; Published: 26 December 2013 (Article); doi: 10.1021/np400802d（影响因子3.17）
2. Tonghan Zhu, et al, Weiming Zhu*, New rubrolides from the marine-derived fungusAspergillus terreus OUCMDZ-1925. J Antibiot 2013, Article ASAP; Publicated: December 11, 2013;doi: 10.1038/ja.2013.135.（影响因子2.19）
2013
1. Yiguang Zhu, et al, Weiming Zhu*, and Changsheng Zhang*, Insights into caerulomycin A biosynthesis: atwo-component monooxygenase CrmH-catalyzed oxime formation. J. Am. Chem. Soc., 2013, 135(50): 18750–18753（影响因子10.68）
2. Yaqin Fan, et al, Weiming Zhu*, Indole-diterpenoids with anti-H1N1 activity from the aciduric fungus Penicillium camemberti OUCMDZ-1492.J Nat Prod 2013, 76(7): 1328–1336.（影响因子3.17）
3. Wenxia Sun, et al, Weiming Zhu,* and Caiguo Huang *, Ophiobolin-O reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human breast carcinoma (MCF-7/ADR) cells. Mar Drugs2013, 11(11): 4570–4584.
4. Pei Wang, et al, Weiming Zhu,*Diketopiperazine derivatives from the marine-derived actinomycete Streptomyces sp. FXJ7.328. Mar Drugs2013, 11(4): 1035–1049.（影响因子3.98）
5. Liping Wang, Weiming Zhu*, Versicolactones A and B: total synthesis and structure revision. Tetrahedron Lett2013, 54(49): 6729–6731（影响因子2.68）
6. Peng Fu, et al, Weiming Zhu*, α-Pyrones from the marine-derived actinomycete Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1. RSC Adv2013, 3(43): 20726–20731.（影响因子2.56）
7. Jinkai Zheng, et al, Weiming Zhu*, Antimicrobial ergosteroids and pyrrole derivatives from halotolerant Aspergillus flocculosus PT05-1 cultured in a hypersaline medium. Extremophiles2013, 17(6): 963-971.（影响因子2.20）
8. Yi Wang, et al, Weiming Zhu*, Developments around the bioactive diketopiperazines: a patent review.Expert Opin Ther Pat. 2013, 23(11): 1415–1433.（影响因子3.52）
2012
1. Peng Fu, et al, Weiming Zhu*, New indolocarbazoles from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135. OrgLett2012, 14(24): 6194–6197. （影响因子6.14）
2. Peng Fu, et al, Weiming Zhu*,Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA. Org Lett 2012, 14(9): 2422–2425.
3. Yiguang Zhu, et al, Weiming Zhu,* Changsheng Zhang*, Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase. Org. Lett. 2012, 14(11):2666–2669.
4. Junfeng Wang, et al, Weiming Zhu*, Cytotoxic Polyphenols from the Fungus Penicillium expansum 091006 endogenous with Mangrove Plant Excoecaria agallocha. Planta Med2012, 78(17): 1861–1866. （影响因子2.15）
2011
1. Peng Fu,et al,Weiming Zhu*, Cyclic bipyridine glycosides from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, Org Lett 2011, 13(22): 5948–5951.
2. Yibin Zhuang, et al, Weiming Zhu*. New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4, OrgLett2011, 13 (5): 1130–1133.
3. Peng Fu, et al, Weiming Zhu*,α-Pyrones and diketopiperazine derivatives from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5, JNatProd2011, 74(10): 2219–2223.
4. Hui Wang,et al,Weiming Zhu*, Anti-influenza virus polyketides from the acid-tolerant fungus Penicillium purpurogenum JS03-21, JNatProd2011, 74(9): 2014–2018.
5. Peng Fu, et al, Weiming Zhu*, Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, JNatProd2011, 74(8): 1751–1756.
6. Yibin Zhuang, et al, Weiming Zhu*, Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4, Tetrahedron, 2011, 67(37): 7085–7089.
7. Zhihong Xu, et al, Weiming Zhu*.Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation, BioorgMedChemLett2011, 21(13): 4005–4007.
2010
1. Jinkai Zheng, et al,Weiming Zhu*,Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorum PT06-1, JNatProd2010, 73(6): 1133–1137.
2. Zhenyu Lu,et al,Kui Hong,* Weiming Zhu.* Cytotoxic polyphenols from the marine-derived fungus Penicillium expansum, J Nat Prod 2010, 73(5): 911–914.
2009
1. Jinkai Zheng,et al,Weiming Zhu*, Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1, Org Lett 2009, 11(22): 5262–5265.
2. Zhenyu Lu, et al, Weiming Zhu*, Sesquiterpenoids and benzofuranoids from the marine-derived fungus Aspergillus ustus 094102, JNatProd2009, 72(10): 1761–1767.
3. Lin Duan, et al, Weiming Zhu*. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans, Planta Med 2009, 75(11): 1241–1245.
2008
1. Hongwen Tao, et al, Weiming Zhu*, Resin glycoside constituents of Ipomoea pes-caprae (beach morning glory), JNatProd2008, 71(12): 1998–2003.
2. Min Zhang, et al, Weiming Zhu*, Cytotoxic alkaloids and antibiotic nor-dammarane triterpenoids from marine-derived fungus Aspergillus sydowi. JNatProd2008, 71 (6): 985–989.
3. Zhenyu Lu, et al, Weiming Zhu*, Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57, JNatProd2008, 71 (4): 543–546.
4. Zhenjian Lin, et al, Weiming Zhu*, Polyketides from Penicillium sp. JP-1, anendophytic fungus associated withthe mangrove plant Aegiceras corniculatum, Phytochemistry 2008, 69(5): 1273–1278. （影响因子3.35）5. Fazuo Wang, et al, Weiming Zhu*, Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus, Tetrahedron 2008, 64(34): 7986–7991.（影响因子3.02）
6. Fazuo Wang, et al, Weiming Zhu*, Six new ergosterols from the marine-derived fungus Rhizopus sp. Steroids 2008, 73(1): 19–26.（（影响因子2.83））
7. Yapeng Zhang, et al, Weiming Zhu*, Isolation, structure elucidation, and antimycobacterial properties of dimeric naphtho-gamma-pyrones from the marine-derived fungus Aspergillus carbonarius, Chem Biodiversity 2008, 5(1): 93–100
2007
1. Wenliang Wang, et al,Weiming Zhu*, Isoechinulin-type alkaloids, variecolorin A-L, from halotolerant Aspergillus variecolor, JNatProd2007, 70(9): 853–855.
2. Wenliang Wang, et al, Weiming Zhu*, Three novel, structurally unique spirocyclic alkaloids from the halotolerant B-17 fungus strain of Aspergillus variecolor, Chem Biodivers 2007, 4(12): 2913–2919.影响因子1.42
3. Dehai Li, et al, Weiming Zhu*, Two new bisorbicillinoids isolated from a deep-sea fungus, Phialocephala sp. FL30r, J Antibiot 2007, 60(5): 317–320.
4. Dehai Li, et al, Weiming Zhu*, Trisorbicillinone A, a novel sorbicillin trimer, from a deep sea fungus, Phialocephala sp. FL30r, TetrahedronLett 2007, 48(30): 5235–5238.
5. Zhi Hong Xin, et al,Wei-Ming Zhu*, Aurantiomides A-C, quinazoline alkaloids from the sponge- derived fungus Penicillium aurantiogriseum SP0-19, J Nat Prod 2007, 70 (5): 853–855.
6. LinDu, et al, Weiming Zhu*, Aspergiolide A, a novel anthraquinone derivative with naphtho[1,2,3-de]chromene-2,7- dione skeleton isolated from a marine-derived fungus Aspergillus glaucus, Tetrahedron 2007, 63(5): 1085–1088.
7. Yapeng Zhang, et al, Weiming Zhu*, Carbonarones A and B, new bioactive gamma-pyrone and alpha-pyridone derivatives from the marine-derived fungus Aspergillus carbonarius, J Antibiot2007, 60(2): 153–157.
2006
1. Rui Liu, Qianqun Gu*, Weiming Zhu*, et al. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans.JNatProd2006, 69(6): 871–875.
2. Li Chen, et al, Weiming Zhu,* Three new sulfated alkenes from the echinus Temnopleurus hardwickii, J Nat Prod 2006, 69 (12): 1787–1789.
3. Rui Liu, Weiming Zhu*, et al, Qianqun Gu*, A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2. J Antibiot 2006, 59(6): 362–365.
2005
1. Weizhong Liu, Qianqun Gu*, Weiming Zhu*, et al,Penicillones A and B, two novel polyketides with tricyclo [5.3.1.03,8] undecane skeleton, from a marine-derived fungus Penicillium terrestre. Tetrahedron Lett2005, 46(30): 4993–4996.影响因子2.51
2. Weizhong Liu, Qianqun Gu*, Weiming Zhu*, et al, Two new benzoquinone derivatives and two new bisorbicillinoids were isolated from a marine-derived fungus Penicillium terrestre, J Antibiot2005, 58 (7): 441–446.
3. Weizhong Liu, Qianqun Gu*, Weiming Zhu*, et al, Dihydrotrichodimerol and tetratrichodimerol, two new bisorbicillinoids, from a marine-derived Penicillium terrestre, J Antibiot 2005, 58 (10): 621–624.
4. Weiming Zhu, et al, Xiaojiang Hao*, Components of stem barks ofWinchia calophylla and their bronchodilator activities, J Integ Plant Biol2005, 47 (7): 892–896.
2001-2004
1. Weiming Zhu, et al, Xiaojiang Hao*, Monoterpenoids and their glycosides from Winchia calophylla, J Asian Nat Prod Res 2004,6(3): 193–198.
2. Weiming Zhu, et al, Xiaojiang Hao*, Two new monoterpene diglycosides from Winchia calophylla A. DC, Chin Chem Lett 2003, 14 (10): 1029–1032.
3. Weiming Zhu, et al, Xiaojiang Hao*, The sesquiterpenoid from Polyalthia cheliensis Hu, Heterocycles2002, 57(3): 529–534.
4. Weiming Zhu, et al, Xiaojiang Hao*, Charles U. Pittman Jr.*, The selective dehydroxylation of 20-hydroxyecdysone by Zn powder and anhydrous acetic acid, Synthetic Comm 2002, 32 (9): 1385–1391.
5. Weiming Zhu, et al, Xiaojiang Hao*, Triterpenoids from the Dai medicinal plant Winchia calophylla, Acta Bot Sin 2002, 44 (3): 354–358.
6. Weiming Zhu, et al, Xiaojiang Hao*, Two new triterpenoid glycosides from Elsholtzia bodinieri Van’t, Chin Chem Lett 2002, 13 (3): 253–255.
7. Weiming Zhu, et al, Xiaojiang Hao*, A new benzosesquiterpenoid dimer from Polyalthia cheliensis, Chin Chem Lett 2001, 12 (7): 617–618.
Group members:
1.Faculty
Dr. Yi Wang, an associateProfessor; M.S. Peipei Liu, an engineer
2.Postdoctor
Dr. Lei Guo; Dr. Xiaolong Huang
3.Ph.D Students
Miss Pei Wang; Mr. Liping Wang; Mr. Kunlai Sun; Mr. Tonghan Zhu; Mr. Fandong Kong; Miss Xiaoqiu Cui; Miss Chengying Zhao; Mr. Hongguang Ma
4.M.S. Students
Miss Yanchao Xu; Miss Qingyun Liao; Mr. Cong Wang; Miss Wenling Wang; Miss Chen Wang; Mr. Zhengbo Chen; Mr. Xiangui Mei; Mr. Yawei Lin; Mr. Haijian Jia; Miss Haishan Liu; Mr. Guoliang Zh
