Individual Resume
Professor Li Yan-Tuan, the PhD supervisor, graduated and received his PhD degree in Sichuan University. He won many honors such as “the National May 1 Labor Medal”,“the outstanding youth intellectuals of Shandong province”, “the ten outstanding college teachers of Shandong province”, “Qingdao professional and technical excellent talents” and so on. He has long been engaged in the research on medicinal synthetic chemistry. Recent years he has lead or shared a dozen of subjects which were included by the national 973 Project, the national 863 Project, the National Natural Science Foundation or provincial and ministerial level researches. Around the subjects, Professor Li has made great progress in the syntheses of targeting bio-macromolecules, novel topoisomerase inhibitors, marine polysaccharide based macromolecule coupling drugs and medicinal intermediates, and the structural modification and optimization of the marinebioactive products. As the corresponding author, he has published over 200 articles in Eur. J. Med. Chem., J. Inorg. Biochem., Cryst. Growth Des. and other international academic journals collected by SCI. His research findings are rewarded by over ten provincial and ministerial science and technology awards and education teaching achievement awards.
Contact Information
Tel: 86-532-82031695
Email: yantuanli@ouc.edu.cn
Address: 5Yushan Road, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, Shandong Province, P. R. China
Enrolment and Cultivation
Enrolling Areas: pharmaceuticalchemistry, pharmaceuticalengineering.
Recent years, he has cultivated 10 doctors, 16 postgraduates. Two of them were rewarded the honor of “the excellent doctor degree dissertation of Shandong province”.
Fields of Research
1. The study on the design and synthesis of antitumor drugs based on targeting bio-molecules
2. The selection and optimization of polymorphic drugs
3. The study on the design and synthesis of the marine polysaccharide based macromolecule coupling drugs
4. The study on the design and synthesis of novel targeting enzyme inhibitors
5. The synthesis study of the medicinal intermediates
6. The structural modification and optimization of the marinebioactive products
The main research topics
1. Director of the project “the clinical study of new anti-cerebral ischemia drugD-polymannuronicate” (No. 2006AA090402, national ocean 863 project of “Eleventh Five-Year Plan”)
2. Director of the project “the study on the design, synthesis and structure-activity relationship of anticancer binuclear complexes targeting Topoisomerase I” (No. 30672515, project supported by the National Natural Science Foundation)
3. Director of the project “the study on the design, synthesis and structure-activity relationship of new anticancer binuclear vanadium complexes” (No. 21071133, project supported by the National Natural Science Foundation)
4. Director of the project “the study on catalyzed hydrolytic kinetics of bridging polynuclear complexes for constructing artificial nuclease” (project supported by the National Natural Science Foundation)
5. Director of the project “the study on the synthesis and anticancer activity of binuclear vanadium complexes targeting Topoisomerase I” (No. 20060423005, Research Fund for the Doctoral Program of MinistryofEducation)
6. Director of the project “the study on marine polysaccharide rare earth complexes” (No.031070115, Science and Technology Development Plan of Shandong Province)
7. Director of the project “the research and development on the Multistage membrane separation and molecularlyimprinted technology applied in the high value utilization of the marine product waste” (No. 2011GHY11521, Science and Technology Development Plan of Shandong Province)
Representative academic publications
1. Yan-Tuan Li*, Zhi-Qiang Liu,Zhi-Yong Wu, One-dimensional copper(II) coordination polymers bridged both by µ-trans-oxamidates and phenyl- dicarboxylates: Synthesis, crystal structure, J. Inorg. Biochem., 2008, 102, 1790.
2. Yu-Lan Song, Yan-Tuan Li*, Zhi-Yong Wu, Synthesis, crystal structure, anti bacterial assay and DNA binding activity of new binuclear Cu(II) complexes with bridging oxamidate, J. Inorg. Biochem., 2008, 102, 1691.
3. Man Jiang, Yan-Tuan Li*, Zhi-Yong Wu, Zhi-Qiang Liu, Cui-Wei Yan, Synthesis, crystal structure, cytotoxic activities and DNA-binding properties of new binuclear copper(II) complexes bridged by N,N'-bis(hydroxylethylamino- ethyl)oxamide, J. Inorg. Biochem., 2009, 103(5), 833-844.
4. Xiao-Wen Li, Yong-Jun Zheng, Yan-Tuan Li*, Zhi-Yong Wu, Cui-Wei Yan, Synthesis and structure of new bicopper(II) complexes bridged by N-(2-aminopropyl)-N’-(2-oxidophenyl)oxamide: The effects of terminal ligands on structures, anticancer activities and DNA-binding properties, Eur. J. Med. Chem., 2011,46, 3851–3857.
5. Yan-Tuan Li*, Wei Sun, Yong-Jun Zheng, Zhi-Yong Wu, Cui-Wei Yan, Synthesis, structure and cyclic voltammetry studies of a 2D sheet-like μ3-hydroxyl- and μ2-, μ4-oxamidato-bridged copper(II) complex, J. Inorg. Organomet. Polym., 2011, 21, 182–188.
6. Yan-Tuan Li*, Wei Sun, Zhi-Yong Wu, Yong-Jun Zheng, Cui-Wei Yan, Synthesis, structure and voltammetric studies of copper(II) polymer with DNA interaction: The first 1-D coordination polymer alternately bridged by oxalate and oxamidate ligands, J. Inorg. Organomet. Polym., 2010, 20, 586–591.
7. Zhi-Qiang Liu, Yan-Tuan Li*, Zhi-Yong Wu, Shu-Fang Zhang, [Cu4(H2O)4(dmapox)2(btc)]n×10nH2O: The first two-dimensional polymeric copper(II) complex with bridging m-trans-oxamidate and μ4-1,2,4,5-benzentetra- carboxylato ligands: Synthesis, crystal structure and DNA binding studies, Inorg. Chim. Acta, 2009, 362, 71–77.
8. Zhi-Qiang Liu, Yan-Tuan Li*, Zhi-Yong Wu, Yu-Lan Song, A two- dimen- sional copper(II) polymer with bridging μ-trans-oxamidate and μ2-picrate ligands: synthesis, crystal structure and DNA binding studies, Inorg. Chim. Acta, 2008, 361, 226-232.
9. Zhi-Qiang Liu, Man Jiang, Yan-Tuan Li*, Zhi-Yong Wu, Jian-Xing Yang, One-dimensional copper(II) polymer with bridging µ-trans-oxamidate and thiocyanate ligands: Synthesis, crystal structure and DNA binding studies, Inorg. Chim. Acta, 2009, 362, 1253-1259.
10. Yan-Tuan Li*, Zhi-Qiang Liu, Zhi-Yong Wu, Man Jiang, Xiao-Wen Li, Synthesis, crystal structure, and DNA-binding studies of a one-dimensional copper(II) polymer bridged both by oxamidate and thiocyanato ligands, Struct. Chem., 2008, 19, 819–826.
Honors and Awards
1.The second prize for science and technology progress of Shandong province via the project “The study on the kinetic mechanism of the electron transfer process” in 1999.
2. The third prize for science and technology progress of Shandong province via the project “The study on the properties of the complexes based on the electron transfer process” in 1998.
3. The third prize for science and technology progress of Shandong province via the project “The study on the properties of the functional molecules based on the electron transfer process” in 2002.
4. The third prize for science and technology progress of Shandong province via the project “The research and development of the high strengthacrylatepressure sensitive adhesive” in 2001.
5. The Science and Technology Development Plan of MinistryofEducationvia the project“The study on the properties of the electron transfer process”in 1999.
6. The third prize for science and technology progress of Shandong province via the project “The study on the mechanism of the electron transfer processand revolving molecular magnetic properties”in 2001.
7. The third prize for science and technology progress of Shandong province via the project “The study on the properties of the mechanism of the electron transfer process” in 1997.
8. The first prize for higher education teaching achievement of Shandong province via the project “The interactive development of teaching and scientific research, the cultivation of pharmaceutical innovative talents” in 2009.
9. The honor of “the National May 1 Labor Medal” in 2001.
10. The honors of “the outstanding youth intellectuals of Shandong province” and “the outstanding youth intellectual nomination prize of Shandong province” in 2001.
11. The honor of “the ten outstanding college teachers of Shandong province” in 2001.
12. He twice won the honor of “Qingdao professional and technical excellent talents” in 2004 and 2008.
