Guoqiang Li
Ph. D, Professor
Traditional Chinese Marine Medicinal Chemistry
Tel: 0532- 82032323(O), 82031535 (lab)；
Email：liguoqiang@ouc.edu.cn
(b. 1963)
B.Sc. 1986Xinjiang University
M. Sc. 1992 Lanzhou University
Ph.D. 2004Ocean University of China-Peking University joint training
Research Fields and Interests：
1. Chemical Foundation of Marine Medicinal Resources
Research of New Marine Biological Resources in the Distant Sea: On the research basis of marine medicinal corals, sponges, mangrove plants, coastal wetland plant in the offshore of South China Sea, in recent years, our researchmainly focusedon new benthic organisms resources in the Xisha and Nansha Islands of open sea area for in-depth chemical diversity and biodiversity. We have obtainedlots of new precious biological resources, sponges and corals, and have discovered many new and novel structural skeletons withstrong anti-tumor activity.
2. R&D of New Traditional Marine Chinese Medicine
R&D of Modern Traditional Chinese Medicine (Traditional Chinese Veterinary Medicine): mainly focused on improving the quality standards oftraditional Chinese marine medicine, standardization research for preclinical registration of new medicine, including the confirmation of chemical structure or composition, preparation process, quality standards, and stability testing. We have cooperated with enterprises to complete many researches, e.g. "fingerprint correlation of Danhong injection (powder for injection)", "fingerprints of injectable Shuxuening and Hedyotis diffusa", "class one new veterinary medicinecomposition and quality standard of Echinaceaand its agents", and "quality standard research of several veterinary drugs".
Grants & Research Projects
1. National Science Foundation:Research on the novel antitumor compounds from four Xisha spongs (41376142, 2014.01-2017.12), leading researcher;
2. National 863 Program (Sub-project):Standardization research of traditional Chinese marine medicines (2013AA093002, 2013-2015), manager;
3. National 863 Program: “Exploring, optimization and synthesis of marine natural products with biological functions”, Sub-project “New natural products from large marine organisms and optimization of the pharmaceutical lead compounds” (No. 2013AA092902, 2013-2015), manager.
Selected Publications：
1. Kai-Kai Gong, Xu-Li Tang, Gang Zhang, Can-Ling Cheng, Xing-Wang Zhang, Ping-Lin Li,* and Guo-Qiang Li*, Polyhydroxylated Steroids from the South China Sea Soft Coral Sarcophyton sp. and Their Cytotoxic and Antiviral Activities. Marine Drugs, 2013,11: 4788-4798.
2. Jinrong Zhang,Xuli Tang,Jing Li,Peifeng Li,Nicole J. de Voogd, Xiaoqin Ni, Xiaojie Jin,Xiaojun Yao,Pinglin Li* and Guoqiang Li*.Cytotoxic Polyketide Derivatives from the South China Sea SpongePlakortis simplex. Journal of Natural Products, 2013, 76:600-606.
3. Gang Zhang, Xuli Tang, Canling Cheng, Kaikai Gong, Xingwang Zhang, Hongyan Zhu, Rongcui Wua, Pinglin Li*, Guoqiang Li.* Cytotoxic 9,11-secosteroids from the South China Sea gorgonianSubergorgia suberosa. Steroids, 2013, 78:845-850.
4. Ting-Ting Li, Xu-Li Tang, Can-Ling Chen, Xing-Wang Zhang, Rong-Cui Wu,Hong-Yan Zhua, Ping-Lin Li*, and Guo-Qiang Li.* New Eunicellin Diterpenes and 9,10-Secosteroids from the Gorgonian Muricella sibogae. Helvetic Chimica Acta, 2013, 96:1188-1196.
5. Caixia Liu, Xuli Tang, Pinglin Li,* and Guoqiang Li*. Suberitine A-D, Four New Cytotoxic Dimeric Aaptamine Alkaloids from the Marine Sponge Aaptos suberitoides. Org. Lett., 2012, 14(8), 1994-1997.
6. Jin-Rong Zhang, Ping-Lin Li, Xu-Li Tang, Xin Qi, and Guo-Qiang Li*. Cytotoxic Tetraprenylated Alkaloids from the South China Sea Gorgonian Euplexaura robusta. Chem. & Biodivers., 2012, 9:2218-2224.
