Qianqun Gu, Prof.
PROFESSIONAL EXPERIENCE
1998-present: Professor, School of Medicine and Pharmacy, Ocean University of China.
EDUCATION
1989-1992: M.Sc. in Pharmacy, Tohoku University, Japan
RESEARCH INTERESTS
Marine Natural Products Chemistry:
1. Discovering the novel compounds with bioactivities from marine derived microorganisms.
2. Studying the structural diversity of secondary metabolites of microorganismsemployed biosynthesis, metabolic regulation, chemical modification, and other interdisciplinary and comprehensive methods;
3. Explore the structure-activity relationshipsbetween molecula targets and bioactive compounds
ORGANIZATION MEMBERSHIPS
Advanced Member of Chinese Pharmaceutical Association
Member of Marine Medicine Professional Committee of China Medicine Instituttion
Member of the Chinese Association of Microorganisms
Editoral Committee of Chinese Journal of Marine Drug
Editoral Committee of Chinese Journal of Antibiotics
GRANTS REVIEWED
1．Chinese National Natural Science Foundation
(1) 2014.1-2017.12Search for novel secondary metabolites from marine microorganisms and studies on their biological activities (No. 21372208)
(2) 2009.1-2012.12 Structural optimization and anti-tumor activity of aspergiolide A (N0. 30973627)
(3) 2008.1-2010.12 Discovery and structural optimization of novel antitumor activity lead compound targeting tyrosine kinase (No. 30772640)
(4) 2005.1-2007.12 Studies on the anti AD activity constituents from endophytic fungi of Cistanche deserticola. (No. 30472136)
2．Scientific and technological major special project_the significant formulation of new drugs
2009.1-2011.12 Study of anti-tumor aspergiolide A, as a drug candidates, from a marine-derived fungus (No. 2009ZX09103-045)
3. Public Projects of State Oceanic Administration
(1) 2010.07. -2014.06.Small molecule compound library construction and screening of active substances from marine derived fungi and actinomycetes(No：2010418022-3)
(2) 2012.7-2014.7. Marine natural product compound libraries (GD2012-D01-001)
PUBLICATIONS (2009-2013)
(1) Wenqiang Guo, Jixing Peng, Tianjiao Zhu, Qianqun Gu, Robert A. Keyzers, and Dehai Li*. Sorbicillamines A-E, Nitrogen Containing Sorbicillinoids from the Deep-sea Derived Fungus Penicillium sp. F23-2. J. Nat. Prod.(2013), 76(11): 2106-2112.
(2) Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurtán, Attila Mándi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu and Dehai Li*. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated Fungus Alternaria sp. JJY-32. J. Nat. Prod. (2013), 76, 1946–1957.
(3) Jixing Peng, Tao Lin, Wei Wang, Zhihong Xin,* Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Antiviral Alkaloids Produced by the Mangrove-Derived Fungus Cladosporium sp. PJX-41. J. Nat. Prod. (2013), 76(6): 1133-1140.
(4) Huquan Gao, Lina Zhou, Shengxin Cai, Guojian Zhang, Tianjiao Zhu, Qianqun Gu and Dehai Li*. Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungus Aspergillus versicolor ZLN-60. J. Antibiot.(2013), 66: 539-542.
(5) Guangwei Wu, Aiqun Lin, Qianqun Gu, Tianjiao Zhu* and Dehai Li*. Four new chloro-eremophilane sesquiterpenes from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Mar. Drugs, (2013), 11: 1399-1408
(6) Shengxin Cai, Yepeng Luan, Xianglan Kong, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Isolation and photo-induced conversion of 6-epi-Stephacidins from Aspergillus taichungensis. Org. Lett. (2013), 15(9): 2168-2171
(7) Qian Che, Tianjiao Zhu, Robert A. Keyzers, Xiaofang Liu, Jing Li, Qianqun Gu, and Dehai Li*. Polycyclic hybrid isoprenoids from a reed rhizosphere-soil derived Streptomyces sp. CHQ-64. J. Nat. Prod.(2013), 76(4): 759-763
(8) Xinying Yang, Guojian Zhang, Xuelian Tang, Jieying Jiao, Sung Yeon Kim, Joo Young Lee, Tianjiao Zhu, Dehai Li, Yong Gab Yun, Qianqun Gu*, Hyun Park*. Toll-like receptor 4/nuclear factor-κB signaling pathway is involved in ACTG-toxin H-mediated anti-inflammatory effect. Mol. Cell Biochem., (2013), 374:29–36
(9) Shengxin Cai, Xianglan Kong, Wei Wang, Huinan Zhou, Tianjiao Zhu, Dehai Li, Qianqun Gu*,Aspergilazine A, a diketopiperazine dimer with a rare N-1 to C-6 linkage,from a marine-derived fungus Aspergillus taichungensis,Tetrahedron Letters 53 (2012) 2615–2617
(10)Jixing Peng, Jieying Jiao, Jing Li, Wei Wang, Qianqun Gu, Tianjiao Zhu*, Dehai Li*, Pyronepolyene C-glucosides with NF-jB inhibitory and anti-influenzaA viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40, Bioorg. Med. Chem. Lett. 22 (2012) 3188–3190
(11) Lin Du, Jing Ai, Dehai Li, Tianjiao Zhu, Ying Wang, Michael Knauer, Torsten Bruhn, Hongbing Liu, Meiyu Geng,* Qianqun Gu,* and Gerhard Bringmann*, Aspergiolides C and D, Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects, Chem. A. Euro. J, (2011) 17 (4) 1319-1326
(12) Li Chen, Tianjiao Zhu, Yuanqing Ding, Ikhlas A. Khan*, Qianqun Gu, and Dehai Li*. Sorbiterrin A, a novel sorbicillin derivative with cholinesterase inhibition activity from the marine-derived fungus Penicillium terrestre. Tetrahedron. Lett.. (2011) 11.038.
(13) Dehai Li, Li Chen, Tianjiao Zhu, Tibor Kurtán,* Attila Mándi, Zhimin Zhao, Jing Li,* and Qianqun Gu*. Chloctanspirones A and B, novel chlorinated polyketides with an unprecedented skeleton, from marine sediment derived fungus Penicillium terrestre. Tetrahedron. (2011) 67 (41): 7913-7918 .
(14) Lin Du, Hongchun Liu, Wei Fu, Dehai Li, Qiuming Pan, Tianjiao Zhu, Meiyu Geng*, and Qianqun Gu*. Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase Iiα inhibitor. J. Med. Chem. (2011) 54, 5796-5810
(15) Guojian Zhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu, Dehai Li* and Qianqun Gu*. Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum. Phytochemistry. (2011) 72, 1436-1442
(16) Shengxin Cai, Tianjiao Zhu, Lin Du, Boyu Zhao, Dehai Li* and Qianqun Gu*. Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor. J. Antibiot. (2011) 64,193-196
(17) Shengxin Cai, Shiwei Sun, Huinan Zhou, Xianglan Kong, Tianjiao Zhu, Dehai Li*, and Qianqun Gu*. Prenylated polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07. J. Nat. Prod. (2011) 74(5): 1106-1110
(18) Fazuo Wang, Hongjuan Wei, Tianjiao Zhu, Dehai Li, Zhenjian Lin and Qianqun Gu*. Three New Cytochalasins from the Marine-Derived Fungus Spicaria elegans KLA03 by Supplementing the Cultures with L- and D-Tryptophan. Chem. Biodivers. (2011) 8(5): 887-894.
(19) Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao and Qianqun Gu*. New Cytotoxic Metabolites from a Deep-Sea-Derived Fungus, Phialocephala sp., Strain FL30r. Chem. Biodivers. (2011) 8(5): 895-901.
(20) Lin Du, Dehai Li, Guojian Zhang, Tianjiao Zhu, Jing Ai, Qianqun Gu*, Novel Carbon-Bridged Citrinin Dimers from a Volcano Ash-Derived Fungus Penicillium citrinum and their cytotoxic and cell-cycle arrest activities, Tetrahedron, (2010) 66 (5) 9286-9290
(21) Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, Qianqun Gu*, Three new sorbicillin trimers, trisorbicillinones B, C and D, from a deep ocean sediment derived fungus, Phialocephala sp. FL30r, Tetrahedron,(2010) 66, 5101-5106
(22) .Lin Du, Teng Feng, Boyu Zhao, Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, Qianqun Gu*. A Alkaloids from a deep ocean sediment derived fungus Penicillium sp. and their antitumor activities, J. Antibiot. (2010) 63, 165-170
(23) Zhenjian Lin, Tianjiao Zhu, and Qianqun Gu*. Spicochalasin A and New Aspochalasins from the Marine-Dirived Fungus Spicaria elegans. Eur. J. Org. Chem.,(2009) 18, 3045-3051
(24) Lin Du, Dehai Li,Tianjiao Zhu,Shengxin Cai,Fengping Wang, Xiang Xiao, and Qianqun Gu*. New alkaloids and diterpenes from a deep ocean sediment derived fungusPenicillium sp.. Tetrahedron,(2009)65,1033-1039
(25) Xinying Yang, Lin Du, Xuelian Tang, Suk-Yul Jung, Bing Zheng, ByoungYul Soh, Sung-Yeon Kim, Qianqun Gu*, and HyunPark. Brevicompanine E reduces lipopolysaccharide-induced production of proinammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-kB.J. Neuroimmunol.,(2009)216, 32-38.
