Principal Investigator:

Wengong Yu is a professor of molecular biology and PhD supervisor in School of Medicine and Pharmacy, Ocean University of China. Prof. Yu graduated from Shandong Medical University on Jul 1988, and earned his MD degree in 1997 at Osaka University. He has been on faculty in OUC since Oct 1998. His research is focused on molecular enzymology, glycobiology and marine drugs. He has published more than 100 papers (over 50 papers were included in SCI/EI) and applied 21 Chinese patents for invention, 8 of which have been granted. He won the second class of innovation award of State Oceanic Administration (2nd, 2003), first class award of State Technological Invention Award (3rd, 2009), topnotch talent of Qingdao (2013).

(see details)

Contact information:

Add: 5 Yushan Road, Qingdao, 266003, China

Tel:0532-82031680

E-mail:yuwg66@ouc.edu.cn

Research interests:

1. Molecular enzymology, mainly R&D of marine polysaccharide degrading enzyme.

2. Research on novel anti-infective agents using bacterial quorum sensing and biofilm as targets.

3. Molecular mechanism of glycosyltransferases and cancer metastasis.

Members:

Qianhong Gong, female, PhD, associate professor. (see details)

Feng Han, male, PhD, associate professor. (see details)

Yuchao Gu, male, MD, associate professor. (see details)

Xinzhi Lu, female, MD, engineer.

Selected publications:

1. Su Ma, Gaofei Duan, Wengang Chai, Cunliang Geng, Yulong Tan, Lushan Wang, Frédéric Le Sourd, Gurvan Michel, Wengong Yu, Feng Han. Purification, cloning, characterization and essential amino acid residues analysis of a new ι-carrageenase from Cellulophaga sp. QY3. PLoS One, 2013, 8(5): e64666. (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064666)

2. Zhanjun Liu, Weishan Wang, Ying Zhu, Qianhong Gong, Wengong Yu, Xinzhi Lu. Antibiotics at subinhibitory concentrations improve the quorum sensing behavior of Chromobacterium violaceum. FEMS Microbiol Lett, 2013, 341(1): 37-44. (http://onlinelibrary.wiley.com/doi/10.1111/1574-6968.12086/pdf)

3. Su Ma, Yulong Tan, Wengong Yu, Feng Han.Cloning, expression and characterization of a new ι-carrageenase from marine bacterium, Cellulophaga sp.. Biotechnol Lett, 2013, 35(10): 1617-1622. (http://link.springer.com/article/10.1007%2Fs10529-013-1244-0)

4. Ya Wang, Enwen Guo, Wengong Yu, Feng Han. Purification and characterization of a new alginate lyase from marine bacterium Vibrio sp.. Biotechnol Lett, 2013, 35(5): 703-708. (http://link.springer.com/article/10.1007%2Fs10529-012-1134-x)

5. Liman Zhou, Hongda Zheng, Yidan Tang, Wengong Yu, Qianhong Gong. Eugenol inhibits quorum sensing at sub-inhibitory concentrations.Biotechnol Lett, 2013, 35(4): 631-637. (http://link.springer.com/article/10.1007%2Fs10529-012-1126-x)

6. Shangyong Li, Panpan Jia, Linna Wang, Wengong Yu and Feng Han. Purification and characterization of a new thermostable κ-carrageenase from the marine bacterium Pseudoalteromonas sp. QY203. J Ocean Univ China, 2013, 12(1): 155-159. (http://www.cnki.com.cn/Article/CJFDTotal-QDHB201301022.htm)

7. Shuai Man, Rubin Cheng, Cuicui Miao, Qianhong Gong, Yuchao Gu, Xinzhi Lu, Feng Han, Wengong Yu. Artificial trans-encoded small non-coding RNAs specifically silence the selected gene expression in bacteria. Nucleic Acids Res, 2011, 39(8): e50. (http://nar.oxfordjournals.org/content/39/8/e50.long)

8. Peng Jiang, Jingbao Li, Feng Han, Gaofei Duan, Xinzhi Lu, Yuchao Gu, Wengong Yu.Antibiofilm activity of an exopolysaccharide from marine bacterium Vibrio sp. QY101. PLoS One, 2011, 6(4): e18514. (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018514)

9. Yulong Tan, Feng Han, Su Ma, Wengong Yu. Carboxymethyl chitosan prevents formation of broad-spectrum biofilm. Carbohydr Polym, 2011, 84(4): 1365-1370. (http://www.sciencedirect.com/science/article/pii/S0144861711000695)

10. Wenyi Mi, Yuchao Gu, Cuifang Han, Haiyan Liu, Qiong Fan, Xinling Zhang, Qi Cong, Wengong Yu. O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy. Biochim Biophys Acta, 2011, 1812(4): 514-519. (http://www.sciencedirect.com/science/article/pii/S0925443911000226)

11. Linna Wang, Shanshan Zou, Shouliang Yin, Hongbing Liu, Wengong Yu, Qianhong Gong. Construction of an effective screening system for detection of Pseudomonas aeruginosa quorum sensing inhibitors and its application in bioautographic thin-layer chromatography. Biotechnol Lett, 2011, 33(7): 1381-1387. (http://link.springer.com/article/10.1007%2Fs10529-011-0563-2)

12. Yuchao Gu, Wenyi Mi, Yuqing Ge, Haiyan Liu, Qiong Fan, Cuifang Han, Jing Yang, Feng Han, Xinzhi Lu, and Wengong Yu. GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis. Cancer Res, 2010, 70(15):6344-6351. (http://cancerres.aacrjournals.org/content/70/15/6344.long)

13. Junli Ye, Yantao Han, Chunbo Wang, Wengong Yu. Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation. J Neurochem, 2009, 111(2):441-451. (http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.06328.x/pdf)

14. Xinzhi Lu, Yan Chu, Qianqian Wu, Yuchao Gu, Feng Han, Wengong Yu. Cloning, expression and characterization of a new agarase-encoding gene from marinePseudoalteromonas sp. BiotechnolLett, 2009,31(10): 1565-1570. (http://www.springerlink.com/content/uu45u866t80756x7)

15. Gaofei Duan, Feng Han, Wengong Yu. Cloning, sequence analysis and expression of genealyPI encoding an alginate lyase from marine bacterium Pseudoalteromonas sp. CY24. Can J Microbiol, 2009, 55(9):1113-1118. (http://www.ncbi.nlm.nih.gov/sites/pubmed/19898554)

16. Yuchao Gu, Junhua Zhang, Wenyi Mi, Jing Yang, Feng Han, Xinzhi Lu, Wengong Yu. Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells. Breast Cancer Res, 2008, 10(1): R1. (http://breast-cancer-research.com/content/10/1/R1)

17. Chao Shi, Xinzhi Lu, Cuiping Ma, Yiming Ma, Xiaoyan Fu, Wengong Yu. Enhancing the thermostability of a novel β-agarase AgaB through directed evolution. Appl Biochem Biotechnol, 2008, 151(1):51-59. (http://www.springerlink.com/content/y6p166401174g737)

18. Han Shi, Yuchao Gu, Jing Yang, Liang Xu, Wenyi Mi, Wengong Yu. Lipocalin 2 promotes lung metastasis of murine breast cancer cells. J Exp Clin Cancer Res, 2008, 27:83. (http://www.jeccr.com/content/27/1/83)

19. YanLing Shi, XinZhi Lu, WenGong Yu. A new β-agarase from marine bacterium Janthinobacterium sp. SY12. World J Microbiol Biotechnol, 2008, 24(11): 2659-2664.(http://www.springerlink.com/content/07xw32286167g866)

20. Xiaochong Shi, Qianhong Gong, Rubin Cheng. Detection of the key enzyme of alginate biosynthesis in Vibrio sp. QY102. World J Microbiol Biotechnol, 2008, 24(8): 1613-1615. (http://www.springerlink.com/content/540j21161512602h)

21. Cuiping Ma, Xinzhi Lu, Chao Shi, Jingbao Li, Yuchao Gu, Yiming Ma, Yan Chu, Feng Han, Qianhong Gong, Wengong Yu. Molecular cloning and characterization of a novel β-agarase, AgaB, from marine Pseudoalteromonas sp. CY24. J Biol Chem, 2007, 282(6): 3747-3754. (http://www.jbc.org/cgi/content/full/282/6/3747)

22. Jingbao Li, Feng Han, Xinzhi Lu, Xiaoyan Fu, Cuiping Ma, Yan Chu, Wengong Yu. A simple method of preparing diverse neoagaro-oligosacharides with β-agarase. Carbohydr Res, 2007, 342(8): 1030-1033. (http://www.sciencedirect.com/science/article/pii/S0008621507000729)

23. Lin Xiao, Feng Han, Zhao Yang, Xinzhi Lu, Wengong Yu. A novel alginate lyase with high activity on acetylated alginate of Pseudomonas aeruginosa FRD1 from Pseudomonas sp. QD03. World J Microbiol Biotechnol, 2006, 22(1): 81-88.(http://link.springer.com/article/10.1007%2Fs11274-005-7713-4)

24. Hongbo Shen, Feng Han, Yuzi Lin, Wengong Yu. A high efficient electroporation of Pseudomonas sp. QDA pretreated with alginate lyase. Enzyme Microb Technol, 2006, 39(4): 677-682.(http://www.sciencedirect.com/science/article/pii/S0141022905005351)

25. Ye Wang, Feng Han, Bin Hu, Jingbao Li, Wengong Yu. In vivo prebiotic properties of alginate oligosaccharides prepared through enzymatic hydrolysis of alginate. Nutr Res, 2006, 26(11): 597-603.(http://www.sciencedirect.com/science/article/pii/S0271531706002260)

26. Bin Hu, Qianhong Gong, Ye Wang, Yiming Ma, Jingbao Li, Wengong Yu. Prebiotic effects of neoagaro-oligosaccharides prepared by enzymatic hydrolysis of agarose. Anaerobe, 2006, 12(5-6): 260-266. (http://www.sciencedirect.com/science/article/pii/S1075996406000539)