Research Contents
The research interests span a wide range which includes tumor, diabetes, neurodegenerative diseases, infectious diseases and other life-threatening diseases. Discovering bioactive natural products which exist novel structures from marine resources, with the application of chemical and biological integrated screening methods, fermentation strategies, and combinatorial biosynthesis metabolic regulation control technologies as well. Furthermore, modifying their structures and studying their structure-activity relationships through chemical derivation and biotransformation to obtain leading compounds of marine drugs with independent intelligent property rights.
Research Fields
1. Screening and Optimizing Fermentation conditions of marine medicinal microorganisms
2. Isolation Identification and Activity Evaluation of active products
3. Combinatorial Biosynthesis and Metabolic Regulation of active products
4. Structure Optimization and Structure-activity relationship of active products
5. Symbiosis of marine microorganisms and hosts
Research Groups
u Lab of Professor Qianqun Gu
Qianqun Gu Master/Professor/Doctoral Supervisor
Tianjiao Zhu Master/Associate Professor/Master’s Supervisor
Dehai Li Ph.D./ Associate Professor/ Master’s Supervisor
u Lab of Professor Weiming Zhu
Weiming Zhu Ph.D./ Professor/Doctoral Supervisor
Yi Wang Ph.D./Lecturer
Peipei Liu Bachelor/Engineer
u Lab of Professor Wenli Li
u Lab of Lecturer Yuchun Fang
Main Achievements
14 national research programs have been conducted over the past 5 years and Laboratory of Marine Natural Products Chemistry has achieved:
1. Established an integrated screening method to discover medicinal microorganisms from marine samples and fermentation strategies of using high yield strain for producing new structural active products.
2. Found out a batch of significant marine medicinal microorganisms while built up a medicinal microorganism repository.
3. Obtained over 400 novel active products and built up a corresponding repository of marine small molecule active compounds. There are two compounds, MDZ-03 and Griseoviridin A, which are targeting at PKC, TopⅡ, and are undergoing preclinical trials as leading compounds for antitumor agents.
4. Published more than 80 papers on Org Lett, Tetrahedron, J Nat Prod and other academic journals which were recorded by SCI. The Lab also possess 40 application of national invention patents. (15 of them have been authorised)
Now there are one postdoctor, 19 PhDs and 30 Masters cultivated by the Lab successfully.
