| Jiaxiang Zhang | Ph.D. | Associate Professor | MasterSupervisor |
Department: | Pharmaceutics Research and Development Center, MBRI |
Phone： | 86-0532-85906825 | Email: | Zhangjiaxiang@ouc.edu.cn |
Address: | 23 Xianggang E Rd, Room C218, Qingdao, Shandong, 266000 |
Research Area: | Polymer-based drug delivery systems research and development Meltextrusion-based pharmaceutical manufacturing process development Additive manufacturing-based novel drug products research and development Solid dispersion, pharmaceutical cocrystals, and control released dosage forms development
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Biography | | | | |
Dr. Zhang`s research focuses on physical pharmacy, industrial pharmacy, and pharmaceutical engineering, specifically on drug delivery, the development of oral sustained and controlled release dosages, as well as the application of hot-melt extrusionand 3D printing technologies for novel drug delivery system development. Dr. Zhangused to work as an ORISE fellow in U.S. FDA.and also completed a cooperation project between UT Austin and Advance Materials Inc., and established a continuous manufacturing platformof hot-melt extrusion of solid dispersion/drug co-crystals. In the recent 5 years, he has published 21 papers in peer-reviewed journals with a total of more than 960 citations, including 2 highly cited articles.He has won the best oral presentation awards of the 2018 CRS annual meeting, the best abstracts awards in AAPS annual meetings, and other awards. Dr. Zhang has 6 and 4 patents patented in China and US, respectively. |
Education | | | | |
2015.01-2018.02 | University of Mississippi | Pharmaceutics | Doctor |
2012.09-2014.05 | New Jersey Institute of Technology | Pharmaceutical Engineering | Master |
2008.09-2012.07 | Northwest University, China | Pharmaceutical Engineering | Bachelor |
Work Experience | | | | |
2022.09-now | Marine Biomedical Research Institute of Qingdao, Pharmaceutics Research and Development Center | Vice Dean |
2022.05-now | Ocean University of China, School of Medicine and Pharmacy | Associate Professor |
2019.10-2021.12 | University of Texas at Austin | | Postdoc |
2018.08-2019.10 | U.S. Food and Drug Administration | CDER/OPQ/DPQR | ORISE fellowship |
2014.05-2014.12 | Polymer Process Institute | | Engineer |
Academic Activities | | | | |
Reviewer of International Journal of Pharmaceutics，Carbonhydrate Polymers，AAPS PharmSciTech，Journal of Drug Delivery Science and Technology，Pharmaceutics |
Research Interests | | | |
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Publications | | | | |
Papers | | | | |
Zhang, J.; Thakkar, R.; Kulkarni, V.R.; Zhang, Y.; Lu, A.; Maniruzzaman, M. Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms. AAPS PharmSciTech2021, 22, 1–14, doi:10.1208/s12249-021-02094-8. Zhang, J.; Lu, A.; Thakkar, R.; Zhang, Y.; Maniruzzaman, M. Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies. Pharm. 2021, Vol. 13, Page 1613 2021, 13, 1613, doi:10.3390/PHARMACEUTICS13101613. Zhang, J.; Thakkar, R.; Zhang, Y.; Maniruzzaman, M. Structure-Function Correlation, and Personalized 3D Printed Tablets Using a Quality by Design (QbD) Approach. Int. J. Pharm. 2020, 590, 378–5173, doi:10.1016/j.ijpharm.2020.119945. Zhang, J.; Thakkar, R.; Zhang, Y.; Maniruzzaman, M. Microwave Induced Dielectric Heating for the On-Demand Development of Indomethacin Amorphous Solid Dispersion Tablets. J. Drug Deliv. Sci. Technol. 2020, 102109, doi:10.1016/j.jddst.2020.102109. Zhang, J.; Xu, P.; Vo, A.Q.; Repka, M.A. Oral Drug Delivery Systems UsingCore–Shell Structure Additive Manufacturing Technologies: A Proof-of-Concept Study. J. Pharm. Pharmacol. 2021, XX, 1–9, doi:10.1093/jpp/rgaa037. Zhang, J.; Xu, P.; Vo, A.Q.; Bandari, S.; Yang, F.; Durig, T.; Repka, M.A. Development and Evaluation of Pharmaceutical 3D Printability for Hot Melt Extruded Cellulose-Based Filaments. J. Drug Deliv. Sci. Technol. 2019, 52, 292–302, doi:10.1016/j.jddst.2019.04.043. Zhang J, Vo AQ, Feng X, Bandari S, Repka MA. Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems. AAPS PharmSciTech. Zhang J, Feng X, Patil H, Tiwari R V., Repka MA. Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int. J. Pharm. 2017;519:186–97. (Highly cited papers) Zhang J, Yang W, Vo AQ, Feng X, Ye X, Kim DW, Repka MA. Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation. Carbohydr. Polym. 2017;177:49– 57, doi:10.1016/j.carbpol.2017.08.058 Öblom H, Zhang J, Pimparade M, Speer I, Preis M, Repka, M, Sandler N., 3D-printed isoniazid tablets for the treatment and prevention of tuberculosis — Personalized dosing and drug release., AAPS PharmSciTech., 2019 (Highly cited papers)
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Patents | | | | |
Mohammed Maniruzzaman, Jiaxiang Zhang, Composition and Cocrystals using Dielectric Heating with Dispersive and Distributive Mixing, PCT/US2021/062768 Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar, Pharmaceutical Composition Containing Cocrystals for Additive Manufacturing, PCT/US2021/046047 Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar, Methods of Producing Pharmaceutical Cocrystals for Additive Manufacturing, PCT/US2021/046048 Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar, Granulesfor 3D Printing Technology, PCT/US2021/032881 Jiaxiang Zhang;Weiwei Yang；An in-line process analytical equipment for pharmaceutical manufacturing process, CN109498455A Jiaxiang Zhang; Weiwei Yang；A 3D printed scalable multi-segment artificial human rib, CN201811133849 Yufeng Zhang, Jiaxiang Zhang，Shuzhen Huang; An exchangeable feeding elements for 3D printer, CN207808507U Yufeng Zhang, Jiaxiang Zhang，Shuzhen Huang;An cooling system for 3D printer nozzle system,CN207649193U Yufeng Zhang, Jiaxiang Zhang，Shuzhen Huang; A feeding system for 3D Printer,CN207808484U Yufeng Zhang, Jiaxiang Zhang，Shuzhen Huang; A holding bed heat system for 3D printer, CN207643726U
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Projects |
Ocean University of China, “Marine Drug Development”, 2022-2027, Principle Investigator Taishan Scholars Program (Youth), 2022-2025
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