HuayueLi,Ph.D.
Associate Professor
Marine Natural Product Biosynthesis Lab
Key Laboratory of Marine Drugs, Ministry of Education
School of Medicine and Pharmacy
Ocean University of China
E-mail: lihuayue@ouc.edu.cn
Phone: (+86)535-82031813
Education:
2006. 09-2011. 02CollegeofPharmacy,PusanNationalUniversity,Korea(Ph.D.)
2004. 09-2006. 08 Department of Biotechnology, Silla University, Korea (M. S.)
2000. 09-2004. 07DepartmentofBiochemistry,YantaiUniversity,China(B.S.)
Positions and Employment:
2014. 07-presentSchool of Medicine and Pharmacy, Ocean University of China, Associate Professor
2011.03-2013. 05 CollegeofPharmacy, PusanNationalUniversity,Korea(Post-doc)
ResearchInterests:
1.Targeted discovery of bioactive natural products from marine microbes using genome-metabolome-bioassay combined strategy.
2.Development and application of 2D-NMR-based metabolomics approaches in high-efficient mining of novel natural products.
Publications:
1.Enjing Jin, Huayue Li*, Zengzhi Liu, Fei Xiao, Wenli Li* Antibiotic Dixiamycins from a Cold-Seep Derived Streptomyces olivaceus. J. Nat. Prod.2021, 84, 2606-2611
2.Huayue Li, Xiao Han, Yujing Dong, Shanshan Xu, Chao Chen, Yingang Feng, Qiu Cui, Wenli Li* Bacillaenes: decomposition trigger point and biofilm enhancement in Bacillus. ACS Omega2021, 6, 1093-1098
3.Zirong Deng, Jing Liu, Tong Li, Huayue Li, Zengzhi Liu, Yujing Dong, Wenli Li* Unusual type II polyketide synthase system involved in cinnamoyl lipid biosynthesis. Angew. Chem. Int. Ed.2021, 60, 153-158
4.Huayue Li, Jing Liu, Zirong Deng, Tong Li, Zengzhi Liu, Qian Che, Wenli Li* Genetic Manipulation of an aminotransferase family gene dtlA activates youssoufenes in marine-derived Streptomyces youssoufiensis. Org. Lett.2020, 22, 729-733
5.Lukuan Hou, Zengzhi Liu, Dongqi Yu, Huayue Li*, Jianhua Ju, Wenli Li* Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorg. Chem.2020, 101, 103954
6.Lu Yang, Lukuan Hou, Huayue Li*, Wenli Li*, Antibiotic angucycline derivatives from the deepsea derived Streptomyces lusitanus. Nat. Prod. Res.2020, 34, 3444-3450
7.Fei Xiao, Sheng Dong, Yang Liu, Yingang Feng, Huayue Li, Cai-Hong Yun, Qiu Cui, and Wenli Li* Structural basis of specificity for carboxyl-terminated acyl donors in a bacterial acyltransferase. J. Am. Chem. Soc.2020, 142, 16031-16038
8.Huayue Li, Xiao Han, Jun Zhang, Yujing Dong, Shanshan Xu, Yilei Bao, Chao Chen, Yingang Feng, Qiu Cui, Wenli Li* An effective strategy for identification of highly unstable bacillaenes. J. Nat. Prod. 2019, 82, 3340-3346
9.Jing Hou, Jing Liu, Lu Yang, Zengzhi Liu, Huayue Li*, Qian Che, Tianjiao Zhu, Dehai Li, Wenli Li*, Discovery of an unusual fatty acid amide from the ndgRyo gene mutant of marine-derived Streptomyces youssoufiensis. Mar. Drugs2019, 17, 12
10.Xiao Han, Lukuan Hou, Jing Hou, Yongyu Zhang, Huayue Li*, Wenli Li*, Heterologous expression of a vioA variant activates cryptic compounds in a marine-derived Brevibacterium strain. Mar. Drugs2018, 16, 191
11.Quanquan Liu, Pengfei Ren, Yang Liu, Wen Qin, Huayue Li*, Wenli Li*, Exploration of the glycosyltransferase BmmGT1 from marine-derived Bacillus strain as potential tool enzyme for compound glycol-diversification. J. Microbiol. Biotechn.2018, 28, 931-937
12.Tingting Yao, Jing Liu, Zengzhi Liu, Tong Li, Huayue Li,Qian Che, Tianjiao Zhu, Dehai Li, Qianqun Gu, Wenli Li* Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery. Nat. Commun.2018, 9, 4091
13.Huayue Li, Huiming Huang, Lukuan Hou, Jianhua Ju, Wenli Li*, Discovery of antimycin-type depsipeptides from a wbl gene mutant strain of deepsea-derived Streptomyces smaliensis SCSIO ZH66 and their effects on pro-inflammatory cytokine production. Front. Microbiol.2017, 8:678
14.HuayueLi, Mingzhi Su,MarkT.Hamann, JohnJ.Bowling, Hyung Sik Kim, JeeH. Jung*, Solution structure of a sponge-derived cystine knot peptide and its notable stability. J. Nat. Prod. (2014) 77, 304-310
15.Huayue Li, John J. Bowling, Mingzhi Su, Jongki Hong, Bong-Jin Lee, Mark T. Hamann, Jee H. Jung*, Asteropsins B-D, sponge-derived knottins with potential utility as a novel scaffold for oral peptide drugs. Biochim. Biophys. Acta – Gen. Subjects (2014) 1840, 977-984
16.Huayue Li, John J. Bowling, Frank R. Fronczek, Jongki Hong, Sairam V. Jabba, Thomas F. Murray, Nam-Chul Ha, Mark T. Hamann*, Jee H. Jung*, Asteropsin A: an unusual cystine-crosslinked peptide from Porifera enhances neuronal Ca2+ influx. Biochim. Biophys. Acta – Gen. Subjects (2013) 1830, 2591-2599
【Close】
