For the endogenous carbohydrate chains such as N, O-glycans, glycolipids, andglycosaminoglycans, the abnormal changes of carbohydrate chains during the development of major diseases such as tumor, diabetes and cardiovascular diseases are discovered using glycomics research techniques. Clarify the role of abnormal carbohydrate chains in the development of related diseases, to provide new strategies for the diagnosis and prevention of diseases. Dig deep and shallow sea algae, to develop new resources of deep-sea and polar microbial carbohydrate, and to use comprehensive biological and chemical methods to carry out carbohydrate high-efficiency preparation and simulation synthesis of compounds, using active screening carbohydrate compounds such as carbohydrate chips and intestinal microbes, and obtaining glyco lead compounds and drug candidate molecules based on the clarification of structure-activity relationship, building a world-leading marine carbohydrate compound entity library and information database; construct technical system for engineering preparation and drug-making of marine carbohydrate drugs, carry out pharmacokinetic study of carbohydrate drugs, clarify the mechanism of absorption, metabolism and transport of carbohydrate drugs; obtain marine carbohydrate innovative drugs and medical materials with independent intellectual property rights.
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