Research Interests
1. Role of cilia and ciliary genes in ciliopathies;
2. Deciphering the mechanisms of scoliosis using zebrafish model system;
3. Development and maintenance of photoreceptor cells;
4. Evolution of nervous system and organ regeneration using placozoa as model system.
Group Members
 |  |  |
Professor Tel: 86 532 82032962 | Dr. KANG Yunsi 康云思 Lecturer Tel: 86 532 82032173 | ZHU Panpan 朱盼盼 Research Assistant Tel: 86 532 82032173 |
Projects
1. Major Program of National Natural Science Foundation of China (NSFC)
2. Excellent Young Scholars Fund Program of National Natural Science Foundation (NSFC)
3. General Program of National Natural Science Foundation of China (NSFC)
4. Taishan Scholars Fund Program of Shandong Province
5. Distinguished Young Scholars Fund Program of Shandong Province
Representative Publications and Achievements
1. Zhao L#, Xie H#, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C*, Huang K*. Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating. Proc Natl Acad Sci U S A. 2021 ,118(17): e2015689118.
2. Luo M#, Lin Z#, Zhu T#, Jin M#, Meng D, He R, Cao Z, Shen Y, Lu C, Cai R, Zhao Y, Wang X, Li H, Wu S, Zou X, Luo G, Cao L, Huang M, Jiao H, Gao H, Sui R*, Zhao C*, Ma X*, Cao M*. Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome. Genet Med (2021).
3.Wang X#, Wang S#, Meng Z, Zhao C. Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish. J Genet Genomics. 2020, 1673-8527(20)30202-2.
4. Xie H#, Kang Y#, Wang S, Zheng P, Zhao C. E2f5 is a versatile transcriptional activator requiredfor spermatogenesis and multiciliated cell differentiation in zebrafish. PLOS Genetics, 2020, 16 (3), e1008655.
5. Zhang X#, Jia S#, Chen Z, Chong YL, Xie H, Feng D, Wu X, Song DZ, Roy S, Zhao C. Cilia-driven cerebrospinal fluid flow directs expression of Urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 2018, 50(12):1666-1673.
6. Han X#, Xie H#, Wang Y, Zhao C. Radial spoke proteins regulate otolith formation during early zebrafish development. FASEB J. 2018, 32(7):3984-3992.
7. Feng D, Chen Z, Yang K, Miao S, Xu B, Kang Y, Xie H, Zhao C. The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. J Bio Chem. 2017, 292(42):17375-17386.
8. Song Z, Zhang X, Jia S, Yelick PC, Zhao C. Zebrafish as a Model for Human Ciliopathies. J Genet Genomics. 2016, 20;43(3):107-20.
9. Zhao C*, Andreeva V, Gibert Y, LaBonty M, Lattanzi V, Prabhudesai S, Zhou Y, Zon L, McCann KL, Baserga S, Yelick PC*. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014, 10(1):e1004074 （co-correspondence）
10. Zhao C, Omori Y, Brodowska K, Kovach P, Malicki J: Kinesin-2 family in vertebrate ciliogenesis. PNAS, 2012, 109(7):2388-93.
11. Zhao C, Malicki J. Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 2011, 30(13):2532-44.
