ZHAO Chengtian 赵呈天
Professor
Ph.D. Biology
Tel: 0532-82032962
Email: chengtian_zhao@ouc.edu.cn
Add.: Ocean University of China, Yushan Campus, Darwin Building, 5 Yushan Road, 266003, Qingdao, P.R.C.
Research Interests
Cilia exist in many phyla from protozoa to mammalian cells and play diverse biological functions. Disruption in cilia function has been linked to many human genetic disorders, collectively termed as ciliopathies. Our lab is interested in the study of mechanisms underlying ciliogenesis using multiple organisms, including zebrafish, placozoa and ciliates. Currently, the main focus of our lab is on the role of cilia and ciliary genes during organogenesis, which includes: 1) The mechanisms of body axis development regulated by cilia-driven cerebrospinal fluid; 2) Degeneration and renewal of photoreceptor cells; 3) Role of cilia and ciliary genes in ciliopathies; 4) Functional evolution of cilia.
Academic Qualifications
1995-1999: B.Sc. Department of Biology, Nanjing University
1999-2006: Ph.D. Department of Biology, Tsinghua University
2006-2009: PostDoc, Medical School, Harvard University
Working Experience
2012-current: Professor, College of Marine Life Sciences, Ocean University of China
2009-2012: Research Associate, Tufts University
Representative Publications
1. Zhao L#, Xie H#, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C*, Huang K*. Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating. Proc Natl Acad Sci USA. 2021 ,118(17): e2015689118. (IF:9.4)
2. Wang X#, Wang S#, Meng Z, Zhao C. Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish. J Genet Genomics. 2020, 1673-8527(20)30202-2. (IF:5.0)
3. Xie H#, Kang Y#, Wang S, Zheng P, Zhao C. E2f5 is a versatile transcriptional activator requiredfor spermatogenesis and multiciliated cell differentiation in zebrafish. PLOS Genetics, 2020, 16 (3), e1008655. (IF:5.2)
4. Zhang X#, Jia S#, Chen Z, Chong YL, Xie H, Feng D, Wu X, Song DZ, Roy S, Zhao C. Cilia-driven cerebrospinal fluid flow directs expression of Urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 2018, 50(12):1666-1673. (IF:27)
5. Han X#, Xie H,# Wang Y, Zhao C. Radial spoke proteins regulate otolith formation during early zebrafish development. FASEB J. 2018, 32(7):3984-3992. (IF:5.6)
6. Feng D, Chen Z, Yang K, Miao S, Xu B, Kang Y, Xie H, Zhao C. The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. J Bio Chem. 2017, 292(42):17375-17386. (IF:4.2)
7. Song Z, Zhang X, Jia S, Yelick PC, Zhao C. Zebrafish as a Model for Human Ciliopathies. J Genet Genomics. 2016, 20;43(3):107-20. (IF:4.6)
8. Zhao C*, Andreeva V, Gibert Y, LaBonty M, Lattanzi V, Prabhudesai S, Zhou Y, Zon L, McCann KL, Baserga S, Yelick PC*. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014, 10(1):e1004074 （co-correspondence）(IF:4.6)
9. Zhao C, Omori Y, Brodowska K, Kovach P, Malicki J: Kinesin-2 family in vertebrate ciliogenesis. PNAS, 2012, 109(7):2388-93. (IF:9.7)
10. Zhao C, Malicki J. Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 2011, 30(13):2532-44. (IF:9.8)
