Dr. Prof. Chang-Yun Wang
Key Laboratory of Marine Drugs,
The Ministry of Education of China
School of Medicine and Pharmacy
Ocean University of China
5 Yushan Road, Qingdao 266003, China
Tel. /Fax.: + + 86-532-82031536
E-mail: changyun@ouc.edu.cn
Professor of Marine Medicinal Bioresources and Marine Natural Products Chemistry
Taishan Scholars (2015)
Experiences:
lPhD, Ocean University of China (1999)
lProfessor, Ocean University of China (1995)
lFormer DAAD scholarship:Bioscience Special Programme, Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany (2000.01-2002.02)
Research Interests:
lMarine natural products chemistry: isolation and structure elucidation of marine bioactive natural compounds from marine invertebrates and their symbiotic microorganisms collected from the South China Sea.
lMarine medicinal bioresources: searching for new marine medicinal bioresources based on marine chemoecological effects focused on marine invertebrates from the coral reefs in the South China Sea.
lMarine traditional Chinese medicines: investigation and development for new drugs of marine traditional Chinese medicines using modern techniques guided by traditional Chinese medicine theory.
Academic Memberships/Assignments:
2011- Member of American Chemical Society (ACS)
1997-Commission of Marine Drugs Special Committee, Pharmaceutical Association of China
2007- Associate director of Marine Biotechnology Special Committee, Marine Medicine Branch of Chinese Medical Association
2012- Vice board chairman of the Council of Marine Biochemistry & Molecular Biology Society, Biochemistry & Molecular Biology Association of China
Awards/Honors:
2005New Century Excellent Talents in Universities, the Ministry of Education of China
Selected Publications:
[1]Yan-Lai Jia#, Mei-Yan Wei#, Hai-Yan Chen, Fei-Fei Guan, Chang-Yun Wang*, Chang-Lun Shao*. (+)- and (−)-Pestaloxazine A, a pair of antiviral enantiomeric alkaloid dimers with a symmetric spiro[oxazinane-piperazinedione] skeleton from Pestalotiopsis sp.. Org. Lett., 2015, 17: 4216-4219.
[2]Lu Liu, Zheng Zhang*, Chang-Lun Shao, Jin-Lan Wang, Hong Bai, Chang-Yun Wang*. Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains. Sci. Rep., 2015, 5(10463): 1−12.
[3]Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Biological and chemical diversity of coral-derived microorganisms. Curr. Med. Chem., 2015, 22: 3707-3762.
[4]Dong-Lin Zhao, Chang-Lun Shao, Li-She Gan, Mei Wang, Chang-Yun Wang*. Chromone derivatives from a sponge-derived strain of the fungus Corynespora cassiicola. J. Nat. Prod., 2015, 78, 286−293.
[5]Dong-Lin Zhao, Chang-Lun Shao, Qiang Zhang, Kai-Ling Wang, Fei-Fei Guan, Ting Shi, Chang-Yun Wang*. Azaphilone and diphenyl ether derivatives from a gorgonian-derived strain of the fungus Penicillium pinophilum. J. Nat. Prod., 2015, 78: 2310–2314.
[6]Qing-Ai Liu, Chang-Lun Shao, Yu-Cheng Gu, Mathias Blum, Li-She Gan, Kai-Ling Wang, Min Chen, Chang-Yun Wang*. Antifouling and fungicidal resorcylic acid lactones from the sea anemone-derived fungus Cochliobolus lunatus. J. Agr. Food Chem., 2014, 62: 3183−3191.
[7]Fei Cao, Chang-Lun Shao, Min Chen, Meng-Qi Zhang, Kai-Xia Xu, Hong Meng,* Chang-Yun Wang*. Antiviral C-25 epimers of 26-acetoxy steroids from the South China Sea gorgonian Echinogorgia rebekka. J. Nat. Prod., 2014, 77, 1488−1493.
[8]Min Chen, Chang-Lun Shao, Xiu-Mei Fu, Chui-Jian Kong, Zhi-Gang She, Chang-Yun Wang*. Lumazine peptides penilumamides B–D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus. J. Nat. Prod., 2014, 77: 1601–1606.
[9]Min Chen, Chang-Lun Shao, Hong Meng, Zhi-Gang She, Chang-Yun Wang*. Anti-respiratory syncytial virus prenylated dihydroquinolone derivatives from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. J. Nat. Prod., 2014, 77, 2720−2724.
[10]Chang-Lun Shao, Ru-Fang Xu, Mei-Yan Wei, Zhigang She*, Chang-Yun Wang*. Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus. J. Nat. Prod., 2013, 76, 779−782.
[11]Min Chen, Chang-Lun Shao, Xiu-Mei Fu, Ru-Fang Xu, Juan-Juan Zheng, Dong-Lin Zhao, Zhi-Gang She*, Chang-Yun Wang*. Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. fungus. J. Nat. Prod., 2013, 76, 547−553.
[12]Jun Qi, Chang-Lun Shao, Zhi-Yong Li, Li-She Gan, Xiu-Mei Fu, Wen-Tao Bian, Hong-Ying Zhao, Chang-Yun Wang*. Isocoumarin derivatives and benzofurans from a sponge-derived Penicillium sp. fungus. J. Nat. Prod., 2013, 76, 571−579.
[13]Cai-Juan Zheng, Chang-Lun Shao, Zhi-Yong Guo, Jian-Feng Chen, Dong-Sheng Deng, Kai-Lin Yang, Yi-Yan Chen, Xiu-Mei Fu, Zhi-Gang She*, Yong-Cheng Lin, Chang-Yun Wang*. Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. fungus. J. Nat. Prod., 2012,75: 189–197.
[14]Kai-Lin Yang, Mei-Yan Wei, Chang-Lun Shao*, Xiu-Mei Fu, Zhi-Yong Guo, Ru-Fang Xu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin, Chang-Yun Wang*. Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp. J. Nat. Prod., 2012, 75: 935–941.
[15]Chang-Lun Shao, Hui-Xian Wu, Chang-Yun Wang*, Qing-Ai Liu, Ying Xu, Mei-Yan Wei|, Pei-Yuan Qian, Yu-Cheng Gu, Cai-Juan Zheng , Zhi-Gang She*, Yong-Cheng Lin. Potent antifouling resorcylic acid lactones from the gorgonian-derived fungus Cochliobolus lunatus. J. Nat. Prod., 2011, 74: 629–633.
