Zhaoxia, Ph. D, Professor
Laboratory of Glycoscience and Glycotechnology
School of Medicine and Pharmacy, Ocean University of China (OUC)
No.5, Yushan Rd., Qingdao, 266003
P. R. China
Tel/Fax: 86-532-82031560
E-mail:zhaoxia@ouc.edu.cn or 1184748799@qq.com
Education:
1.1990: B.Sc. Chemistry, OUC
2.1999: M.Sc. Marine drug, OUC
3.2007: Ph.D. Carbohydrate-based pharmaceutics, OUC
Working background
1.1990-1991: Workshop Manager, Xiyuan Pharmaceutical Factory of Yantai, Shandong
2.1991-1994: Assistant Researcher, Institute of Marine Drug and Food, OUC
3.1994-1998: Manager of Technical Development Department, Huahai Pharmaceutical Factory of Qingdao.
4.1999-2002: Lecturer, Institute of Marine Drug and Food, OUC
5.2003-2010: Associate Professor, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, OUC
6.2011-: Professor, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, OUC
Teaching:
1.Chemical pharmaceutical technology, for undergraduate students.
2.Pharmaceutics, for undergraduate students.
3.Introduction to Carbohydrate-based drugs, for undergraduate students.
4.Sturcture and Function of Glycoconjugates, for master degree students.
Research Interests:
1.Extraction, Separationand structural characterization of marine polysaccharides and oligosaccharides.
2.Quality analysis of carbohydrate-based drug and microanalysis of carbohydrates in biological samples.
3.Research and development of carbohydrate-based pharmaceutics.
Awards:
1.Scientific Research Achievements Award of Shandong colleges and universities, 2007
2.Marine Innovation Award of National Ocean Bureau of China, 2007
3.Invention Award of Ministry of Education of China, 2008
4.Teaching Quality Evaluation Excellence Award of OUC, 2009
5.Excellent Teaching Award of OUC,2010
6.Excellent InstructorAward of Challenge Cup Undergraduate Extracurricular Scientific Work Competition of ShandongProvince,2012
Research Projects:
1.Anti-urolithiasis effects and structural characterization of polyguluronate sulfate. National Key Technology R&D Program of China (2002AA2Z3145), 2002-2005
2.Clinical study and industrialization of chitosan ester as an antiatherosclerosis marine drug, National High Technology Research and Development Program (863) of China (2002AA624020), 2002-2005, Co-researcher
3.Fine structural characterization of a fungi glycoprotein with anticanceractivity. Natural Science Foundation of China (30370345), 2004-2006, Co-researcher
4.Preclinical study of anti-type 2 diabetes marine oligosaccharide drug HS203, National High Technology Research and Development Program (863) of China (2007AA09Z445), 2007-2010, Co-researcher
5.Construction of bio-glycochip and study of marine carbohydrate structure and function, International Scienceand Technology Collaboration Program of China (No. 2007DFA30980),2008-2010, Co-researcher
6.Interaction of marine acidic oligosaccharidesto islet amyloid polypeptide, Natural Science Foundation of China (No. 30870506), 2009-2011
7.Marine functional oligosaccharides and their medicinal development technologies, Special Fund for Marine Scientific Research in the Public Interest of China(No.201005024), 2010-2015, Co-researcher
8.Development of technical system of marine oligosaccharides preparation, Qingdao Science & Technology Project (11-2-2-1-hy), 2011-2013
9.Development technology of high value marine oligosaccharides, National Key Technology R&D Program of the Ministry of Science and Technology (No.2013BAB01B02), 2013-2016, Co-researcher
Selected Publications:
1.Ting Hu, Chunxia Li, Xia Zhao, Guangsheng Li, Guangli Yu, Huashi Guan. Preparation and characterization of guluronic acid oligosaccharides degraded by a rapid microwave irradiation method.Carbohydrate Research, 2013, 373: 53-58
2.Shumeng Sun, Xia Zhao, Guangli Yu, Guangsheng Li. Fluorescence Labeling Strategies for Different Structural Carbohydrates. Chinese Journal of Biochemistry and Molecular Biology, 2012, 28(1): 18-27
3.Shumeng Sun, Xia Zhao, Guangsheng Li, Guangli Yu, Xiaoxu Xing, Yangyang Zeng, Jian Wu, Jianing Wang. Microanalysis of oligosaccharide HS203 in beagle dog plasma by postcolumn fluorescence derivatization method. Carbohydrate Polymers, 2012, 89(2): 661-666
4.Bo Yang, Guangli Yu, Xia Zhao, Weina Ren, Guangling Jiao, Lianhua Fang, Yuehua Wang, Guanhua Du, Christa Tiller, Gabrielle Girouard, Colin J. Barrow, H. Stephen Ewart, Junzeng Zhang. Structural characterisation and bioactivities of hybrid carrageenan-like sulphated galactan from red alga Furcellaria lumbricalis, Food Chemistry, 2011, 124(1):50-57
5.Xia Zhao, Guang-sheng Li, Guang-li Yu, Jin-xia Wang, Hao Wang, Shu-meng Sun, Chen Zheng. Analysis of oversulfated chondroitin sulfate in contaminated heparin by precolumn derivatization high performance liquid chromatography, Chemical journal of chinese universities, 2010, 31 (3): 479-483
6.Bo Yang, Guangli Yu, Xia Zhao, Guangling Jiao, Sumei Ren，Wengang Chai. Mechanism of mild acid hydrolysis of galactan polysaccharides with highly ordered disaccharide repeats leading to a complete series of exclusively odd-numbered oligosaccharides.FEBS J. 2009, 276(7): 2125-2137
7.Xia Zhao, Guangli Yu, Nan Yue, Huashi Guan. Effects of low-molecular-weight polyguluronate sulfate on experimental urolithiasis in rats. Urological research, 2007, 35(6):301-306
8.Xia Zhao, Guangli Yu, Huashi Guan, Nan Yue, Zhenqing Zhang, Haihua Lia. Preparation of low-molecular-weight polyguluronate sulfate and its anticoagulant and anti-inflammatory activities. Carbohydrate Polymer, 2007, 69(2): 272-279.
9.Zhenqing Zhang, Guangli Yu, Xia Zhao, Haiying Liu, Huashi Guan, Alexander M. Lawson and Wengang Chai. Sequence Analysis of Alginate-Derived Oligosaccharides by Negative-Ion Electrospray Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 2006, 17, 621-630
10.Guangli Yu, Xia Zhao, Bo Yang, Sumei Ren, Huashi Guan, Yibing Zhang, Alexander M. Lawson, and Wengang Chai. Sequence Determination of Sulfated Carrageenan-Derived Oligosaccharides by High-Sensitivity Negative-Ion Electrospray Tandem Mass Spectrometry. Analytical Chemistry, 2006, 78, 8499-8505
