1. Study on preparation and property evaluation of biomedical materials from marine natural polysaccharides;
2. Derivatization modification, characterization and activity analysis of marine active substances;
3. Marine enzymes and biochemical products.
Dr. HAN Baoqin 韩宝芹
Dr. PENG Yanfei 彭燕飞
Dr. YANG Yan 杨艳
Dr. CHANG Jing 常菁
Dr. JIANG Zhiwen 蒋志雯
1 projects of General Program of National Natural Science Foundation of China (NSFC)
1 projects of Young Scientists Fund Program of National Natural Science Foundation (NSFC)
1 project of National Key Research and Development Program of China
1 project of Key Research and Development Program of Shandong Province
Representative Publications and Achievements
1.Xia Lixin#, Wang Shuo#, Jiang Zhiwen, Chi Jinhua, Yu Shuqin, Li Hongjian, Zhang Yijie, Li Lihua, Zhou Changren, Liu Wanshun, Han Baoqin*. Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats. Carbohydrate Polymers, 2021, 264: 11796.
2.Wang Shuo, Chia Jinhua, Jiang Zhiwen, Hu Huiwen, Yang Chaozhong, Liu Wanshun, Han Baoqin*. A self-healing and injectable hydrogel based on water-soluble chitosan and hyaluronic acid for vitreous substitute. Carbohydrate Polymers, 2021, 256: 117519.
3.Xiaotong Chen#, Junxiang Gu#, Le Sun, Wenya Li, Lili Guo, Zhiyang Gu, Litong Wang, Yan Zhang, Wangwang Zhang, Baoqin Han, Jing Chang*. Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives. Bioactive Materials, 2021, 6(10), 3025-3035.
4.Jiang Zhiwen, Wang Shuning, Hou Jun, Chi Jinhua, Wang Shuo, Shao Kai, Liu Wanshun, Sun Rongju*, Han. Baoqin*. Effects of carboxymethyl chitosan oligosaccharide on regulating immunologic function and inhibiting tumor growth. Carbohydrate Polymers, 2020, 250: 116994.
5.Chi Jinhua, Jiang Zhiwen, Chen Xiaotong, Peng Yanfei, Liu Wanshun, Han Baosan*, Han Baoqin*. Studies on anti-hepatocarcinoma effect, pharmacokinetics and tissue distribution of carboxymethyl chitosan based norcantharidin conjugates. Carbohydrate Polymers, 2019, 226: 115297.
6.Chi Jinhua, Jiang Zhiwen, Qiao Jing, Peng Yanfei, Liu Wanshun, Han Baoqin*. Synthesis and anti-metastasis activities of norcantharidin-conjugated carboxymethyl chitosan as a novel drug delivery system. Carbohydrate Polymers, 2019, 214: 80–89. (IF: 7.182)
7.Jiang Zhiwen, Song Yanan, Qiao Jing, Yang Yan, Zhang Wei, Liu Wanshun, Han Baoqin*. Rat sciatic nerve regeneration across a 10-mm defect bridged by a chitin/CM-chitosan artificial nerve graft. International Journal of Biological Macromolecules, 2019, 129: 997-1005.
8.Chi Jinhua, Jiang Zhiwen, Qiao Jing, Zhang Wei, Peng Yanfei, Liu Wanshun, Han Baoqin*. Antitumor evaluation of carboxymethyl chitosan based norcantharidin conjugates against gastric cancer as novel polymer therapeutics. International Journal of Biological Macromolecules, 2019, 136: 1-12.
9.Qiao Jing, Liu Yuying, Jiang Zhiwen, Yang Yan, Liu Wanshun, Han Baoqin*. Preparation and renoprotective effects of carboxymethyl chitosan oligosaccharide on adriamycin nephropathy. Carbohydrate Polymers, 2018, 201: 347-356.
10.Jiang Zhiwen, Chi Jinhua, Han Baoqin*, Liu Wanshun. Preparation and pharmacological evaluation of norcantharidin-conjugated carboxymethyl chitosan in mice bearing hepatocellular carcinoma. Carbohydrate Polymers, 2017, 174: 282-290.