Liu Weizhi 刘伟治
Professor
Ph.D. Biology
Tel:
Email:liuweizhi@ouc.edu.cn
Add.: Ocean University of China, Yushan Campus, Science Building, 5 Yushan Road, 266003, Qingdao, P.R.C.
Research Interests
Structure/function relationship of protein;
Assembly mechanism of marine adhesive protein;
Marine biomaterial;
Marine enzymes involve in polysaccharides synthesis, metabolism and modification;
Protein engineering
Academic Qualifications
1996-2000: B.Sc. Biochemistry , Yantai University
2000-2003: M.Sc. Biochemistry , Ocean University of China
2003-2006: Ph.D. Drug Design, Shanghai Institute of Materia Medica Chinese Academy of Sciences
2006-2010: PostDoc, University of Colorado Health Sciences Center
Working Experience
2012-current: Professor, College of Marine Life Sciences, Ocean University of China
2011-2012: Associate Research Scientist, Department of Pharmacology, Yale University
2010-2011: Postdoctoral Associate, Department of Pharmacology, Yale University
Representative Publications
1. Zhang Keke, Liu Tao, Liu Weizhi*, Lyu Qianqian*. Structural insights into the substrate-binding cleft of AlyF reveal the first long-chain alginate-binding mode. Acta Crystallogr D Struct Biol. 2021. D77, 336-346.
2. Lyu Qianqian, Zhang Keke, Shi Yanhong, Li Weihua, Diao Xiaotong, Liu Weizhi*. Structural insights into a novel Ca2+-independent PL-6 alginate lyase from Vibrio OU02 identify the possible subsites responsible for product distribution. BBA-General Subjects, 2019, Jul; 1863(7):1167-1176.
3. Zhang Xiaokang#; Dai Xiaoting#; Wang Lulu; Miao Yan; Xu Pingping; Liang Pengyu; Dong Bo; Bao Zhenmin; Wang Shi; Lyu Qianqian*; Liu Weizhi*, Characterization of an atypical metalloproteinase inhibitors like protein (Sbp8-1) from scallop byssus, Frontiers in Physiology. 2018 May 23;9:597.
4. Xu Pingping#, Dai Xiaoting#, Wang Dandan, Miao Yan, Zhang Xiaokang, Wang Shuoshuo, Teng Luyao, Dong Bo, Bao Zhenmin, Wang Shi, Lyu Qianqian*, Liu Weizhi*, The discovered chimeric protein plays the cohesive role to maintain scallop byssal root structural integrity. Scientific Reports, 2018 Nov 20;8(1):17082.
5. Lyu Qianqian, Zhang Keke, Zhu Qiaoyun, Li Zhijian, Liu Yujie, Fitzek Elisabeth, Yohe Tanner, Zhao Liming, Li Weihua, Liu Tao, Yin Yanbin, Liu Weizhi*. Structural and biochemical characterization of a multidomain alginate lyase reveals a novel role of CBM32 in CAZymes. BBA-General Subjects, 2018, 1862(9):1862-1869.
6. Oligosaccharides of Chitin and Chitosan: Bio-manufacture and Applications, Springer, (chapter 3: Preparation of Chitooligosaccharides and Its Monomer), Weizhi Liu*, Qianqian Lyu, Zhen, Qin.
