Associate Professor, Laboratory of Marine Stock Enhancement & Conservation

Department of Marine Fisheries, Fisheries College

Ocean University of China

5 Yushan Road, Qingdao 266003, P. R. China            

Email: chenmuyan@ouc.edu.cn

EDUCATION

BS, Fishery Resources and Environment, Ocean University of China 2001

MS, Fish Behavior and Physiology, Ocean University of China, 2004

PhD, Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 2007

RESEARCH

Research Interests:

My research focuses on molecular physiology of sea cucumber.

Research experience:

2010-2011 Visiting Assistant Researcher, Department of Developmental and Cell Biology, University of California, Irvine

2009 Assistant Professor, Institute of Oceanology, Chinese Academy of Sciences.

2007–2009 Post-doc, Department of Pharmaceutical and Biomedical Sciences, University of South Carolina, USA.

Current Research Projects (recent 5 years):

§ The expression profile and the emerging roles of microRNAs inresponse to hypometabolism in aestivating sea cucumber, National Natural Science Foundation of China (Grant No. 31201972), 2013-2015

§ The expression profile analysis of microRNAs in response to hypometabolism in aestivating sea cucumber, Research Fund of young scholars for the Doctoral Program ofHigher Education of China (No. 20120132120009), 2013-2015

PUBLICATION (recent 10 years)

Muyan Chen*, Xiumei Zhang, Jianning Liu, Kenneth B. Storey (2013). High-throughput sequencing reveals differential expression of miRNAs in intestine from sea cucumber during aestivation. PLoS ONE, 8, e76120. (Corresponding author) (IF=3.73)

Lina Sun, Hongsheng Yang, Muyan Chen*, Deyou Ma, Chenggang Lin (2013). RNA-Seq Reveals Dynamic Changes of Gene Expression in Key Stages of Intestine Regeneration in the Sea Cucumber Apostichopus japonicus. PLoS ONE, 8(8): e69441 (Corresponding author) (IF=3.73)

Ye Zhao, Muyan Chen*, Lin Su, Tianming Wang, Shilin Liu, Hongsheng Yang (2013). Molecular cloning and expression-profile analysis of sea cucumber DNA (Cytosine-5)-methyltransferase 1 and methyl-CpG binding domain type 2/3 genes during aestivation. Comp Biochem Physiol, Part B, 165(1): 26-35 (Corresponding author) (IF=1.923)

Lina Sun, Hongsheng Yang, Muyan Chen*, Dongxue Xu (2013). The cloning and expression analysis of Wnt6 and Hox6 during intestine regeneration in the sea cucumber Apostichopus japonicus. Genet Mol Res, 12 (4): 5321-5334 (Corresponding author) (IF=1.2)

Kiril L Hristov*, Muyan Chen*, Serge A.Y. Afeli, Qiuping Cheng, Eric S Rovner, and Georgi V. Petkov (2012). Expression and function of KV2-containing channels in human urinary bladder smooth muscle. Am J Physiol Cell Physiol, 302, C1599-C1608 (Co-first author) (IF=3.817)

Lina Sun, Muyan Chen*, Hongsheng Yang, Tianming Wang, Baozhong Liu, Cynthia Shu, David M. Gardiner (2011). Large Scale Gene Expression Profiling during Intestine and Body Wall Regeneration in the Sea Cucumber Apostichopus japonicus. Comp Biochem Physiol, Part D, 6, 195-205 (Corresponding author) (IF=2.8)

Chen MY, Kellett W.F. Petkov GV. (2010) Voltage-gated K+ channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle. Am J Physiol- Regulatory, Integrative and Comparative Physiology. 299, 177-184 (IF=3.792)

Chen MY, Petkov GV. (2009) Identification of large conductance Ca2+-activated K+ channel accessory β4 subunit in rat and mouse urinary bladder smooth muscle. Journal of Urology, 182, 374-381 (IF=3.862)

Xu B, Chen MY, Yang HS, Zhao SJ. (2008) Starvation-induced changes of hemocyte parameters in Chlamys farreri. Journal of shellfish research, 27, 1-5. (Co-first author)(IF=1.041)

Chen MY, Yang HS, Xu B, Wang FY, Liu BZ. (2008) Catecholamine responses to environmental stress in the hemolymph of Zhikong scallop chlamys farreri. Journal of Experimental Zoology, 309A, 289-296 (IF=1.608)

Chen MY, Yang HS, Delaporte M, Zhao SJ. (2007) Immune response of the scallop Chlamys farreri after air exposure to different temperatures. Journal of Experimental Marine Biology and Ecology, 345, 52-60 (IF=2.263)

Chen MY, Yang HS, Delaporte M, Zhao SJ (2007). Immune Condition of Chlamys farreri in Response to Acute Temperature Challenge. Aquaculture, 271, 479-487. (IF=2.009)

Chen MY, Yang HS, Shi FF (2007) Selection of anticoagulant solution to the hemolymph of Chlamys farreri by TEM and flow cytometry. High Technology Letters, 13, 87-91

Kiril L. Hristov, Muyan Chen, Whitney F. Kellett, Rover ES and Georgi V. Petkov (2011). Large conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function. Am J Physiol Cell Physiol, 301, C903-C912 (IF=3.817)

Hristov KL, Chen M, Soder RP, Parajuli SP, Cheng Q, Kellett WF, Petkov GV (2011). KV2.1 and electrically silent KV channel subunits control excitability and contractility of Guinea pig detrusor smooth muscle. Am J Physiol Cell Physiol, 302(2):C360-C372 (IF=3.817)

Tianming Wang, Hongsheng Yang, Huan Zhao, Muyan Chen, Bing Wang (2011). Transcriptional changes in epigenetic modifiers associated with gene silencing in the intestine of the sea cucumber Apostichopus japonicus (Selenka), during aestivation. Chinese J Oceanol Limnol, 29, 1267-1274

Huan Zhao, Hongsheng Yang, Heling Zhao, Muyan Chen, Shilin Liu (2011). Heat stress-mediated gene expression in the body wall of Japanese sea cucumber (Apostichopus japonicus). Aquatic Biology, 12, 23-31 (IF=1.611)

Huan Zhao, Hongsheng Yang, Heling Zhao, Muyan Chen, Tianming Wang (2011). The molecular characterization and expression of heat shock protein 90 (Hsp90) and 26 (Hsp26) cDNAs in sea cucumber (Apostichopus japonicus). Cell Stress and Chaperones, 16, 481-493 (IF=2.167)

Sean M. Brown, Lilia M. Bentcheva-Petkova, Lei Liu , Kiril L. Hristov, Muyan Chen, Whitney F. Kellett, Andrea L. Meredith, Richard W. Aldrich, Mark T. Nelson and Georgi  V. Petkov. (2008) β–adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large conductance Ca2+-activated K+ channel. AJP-Renal Physiology, 295, F1149-F1157 (IF=3.792)

Xing K, Yang HS, Chen MY. (2008) Morphological and ultrastructural characterization of the coelomocytes in Apostichopus japonicus. Aquatic Biology, 2, 85-92. (IF=1.453)

Chen MY, Zhang XM, Gao TX, Chen C (2006) Effects of Temperature, pH and NaCl on Protease Activity in Digestive Tract of Young Turbot, Scophthalmus maximus. Chinese Journal of Oceanology and Limnology, 24, 300-306.